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Using CIDRs to Improve Pregnancy Rates

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ETschool
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Using CIDRs to Improve Pregnancy Rates

Postby ETschool » Tue Mar 28, 2017 7:19 am

There have been many attempts to improve pregnancy rates by administering progesterone (PG) from injections to vaginal suppositories. Unfortunately, results have been well below expectations but have improved with the advent of controlled intravaginal releasing devices (CIDRs) for synchronizing estrus improving CLs (corpora lutea) resulting in larger follicles producing higher quality eggs.

CIDRs contain 1.9g of P4. They release 610mg of P4 averaging 87mg/day into the blood stream of the cow. High producing dairy cows metabolize high rates of P4 due to the large blood liver flow. Therefor one CIDR increases P4 by only 0.78ng/ml in a lactating cow after 7 days of application, compared to 4 to 5.8ng/ml in an untreated cow. From these findings one CIDR is insufficient to improve P4 levels needed to sustain a CL resulting in larger follicles and improved quality of eggs.

Recent studies with lactating cows (under stress due to milk production) have reported increased pregnancy rates when two CIDRs are inserted. It would seem reasonable to assume the same results are achieved in beef cattle under stress for example sudden large changes in temperature over a few hours, insufficient energy in a ration, too fat for optimum breeding and possibly too frequent synchronization and superovulation efforts. Therefore, it was hypothesized that two CIDRs in a difficult situation could improve pregnancy rates by obtaining better quality eggs.

In a recent study 1160 Holsteins of which 326 (29%) had no CL thus significantly reducing rates of circulating P4. Cows were divided into two randomized groups, one group received one CIDR and the second group received two CIDRs vaginally inserted. After removal of the CIDRs followed by heat, 7 days later cows were implanted with 7 day embryos. The cows recording low P4 and missing a CL (due to stress) at the start of the synchronizing and superovulation treatment and given two CIDRs resulted in higher pregnancy rates at Day 60 (27.6%) compared to the one CIDR cows. Previous studies have shown that increased P4 during follicular development can alter early embryo development and quality.

In conclusion it maybe judicious to attempt the two CIDR protocol for estrous synchronization when cows have been stressed or routinely produce poor quality embryos.

Dr. Peter Elsden
Owner / Instructor
International Embryo Transfer School
http://www.ETschool.com

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VB RANCH
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Re: Using CIDRs to Improve Pregnancy Rates

Postby VB RANCH » Tue Mar 28, 2017 9:15 am

Looks like maybe
some one otta
build a double strength cidr
I use them in my 1st calf hfrs
with good results

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Re: Using CIDRs to Improve Pregnancy Rates

Postby LCP » Tue Mar 28, 2017 6:03 pm

I'm sure the science is sound, but I'm a little skeptical of the economics and propping-up of poor fertility animals. I cringe to think how this kind of thing is used to replicate "valuable" animals, whose progeny are supposed to go into commerical herds. Judicious to me would be if they don't breed, send them to town and don't keep any daughters.

Would love to hear Greg Golden's thoughts on this subject...I'm sure they would be entertaining.

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Silver
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Re: Using CIDRs to Improve Pregnancy Rates

Postby Silver » Thu Mar 30, 2017 12:06 pm

I was thinking the same thing LCP.
Time and energy I think are better spent picking good replacements and growing them out with good quality feed so their reproductive systems are mature and healthy when they go out to breed.

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Faster horses
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Re: Using CIDRs to Improve Pregnancy Rates

Postby Faster horses » Thu Mar 30, 2017 6:50 pm

Silver wrote:I was thinking the same thing LCP.
Time and energy I think are better spent picking good replacements and growing them out with good quality feed so their reproductive systems are mature and healthy when they go out to breed.


:agree:
"All the Democrats know how to do is lie and “forget.”--Trey Gowdy

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Re: Using CIDRs to Improve Pregnancy Rates

Postby WB » Fri Mar 31, 2017 5:55 am

i prefer the select sync protocol and skip the cider. A little more work yes but I feel I get more cows pregnant in shorter timeline with fewer opens. Not for everyone I know but it works well here. It is cheaper also.

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Re: Using CIDRs to Improve Pregnancy Rates

Postby Mike » Fri Mar 31, 2017 7:50 am

Is Estradiol Benzoate legal to use anymore? Don't remember the protocol exactly, but we had over 75% success with two groups of time bred cattle about 20 years ago.. Someone told me not long ago he couldn't find any.
I'd rather have a bottle in front of me than a frontal lobotomy.


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