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Creekstone should test for uranium in Peyer's Patches.

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Kathy

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Since the USDA (and for that matter, the Canadian Food Inspection Agency) won't allow private testing for BSE, perhaps Creekstone and others wishing to find out if their slaughter animals are "predisposed" to BSE - could test the Peyer's Patches found in the distal ileum, and considered "specified risk material", for uranium.

Note how this study demonstrates that yeast, often used in the creation of man-made prion strains, stores uranium in a different way than other metals:

Appl Microbiol Biotechnol, 1995 Jan, 42(5), 797 - 806

Biosorption of heavy metals by Saccharomyces cerevisiae;
Volesky B et al.;

Abundant and common yeast biomass has been examined for its capacity to sequester heavy metals from dilute aqueous solutions . Live and non-living biomass of Saccharomyces cerevisiae differs in the uptake of uranium, zinc and copper at the optimum pH 4-5 . Culture growth conditions can influence the biosorbent metal uptake capacity which normally was: living and non-living brewer's yeast: U > Zn > Cd > Cu; non-living baker's yeast: Zn > (Cd) > U > Cu; living baker's yeast: Zn > Cu approximately (Cd) > U . Non-living brewer's yeast biomass accumulated 0.58 mmol U/g . The best biosorbent of zinc was non-living baker's yeast (approximately 0.56 mmol Zn/g) . Dead cells of S . cerevisiae removed approximately 40% more uranium or zinc than the corresponding live cultures . Biosorption of uranium by S . cerevisiae was a rapid process reaching 60% of the final uptake value within the first 15 min of contact . Its deposition differing from that of other heavy metals more associated with the cell wall, uranium was deposited as fine needle-like crystals both on the inside and outside of the S . cerevisiae cells.

hmm... the "uranium was deposited as a fine needle-like crystal"..... sure sounds like the uranium is capable of forming the metal seed required for nucleation of proteins....

google Saccharomyces cerevisiae and prions!

Metal nucleating clusters as described by Dr. Vitaly Vodyanoy:

United States Patent Application 20070122799
Kind Code A1
Vodyanoy; Vitaly J. ; et al. May 31, 2007

--------------------------------------------------------------------------------
Method of isolation and self-assembly of small protein particles from blood and other biological materials


Abstract
Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed "proteons" are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed "proteon nucleation center" (PNC). Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form.

Link to Vodyanoy's research on this topic:
http://ott.auburn.edu/overview/PNC-Misfolded-Proteins.pdf


Toxicology. 2006 Oct 29;227(3):227-39. Epub 2006 Aug 17. Links
Absorption, accumulation and biological effects of depleted uranium in Peyer's patches of rats.
Dublineau I, Grison S, Grandcolas L, Baudelin C, Tessier C, Suhard D, Frelon S, Cossonnet C, Claraz M, Ritt J, Paquet P, Voisin P, Gourmelon P.
IRSN, Direction de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de Radiotoxicologie expérimentale, IRSN, BP 17, F-92262 Fontenay-aux-Roses Cedex, France. [email protected].

The digestive tract is the entry route for radionuclides following the ingestion of contaminated food and/or water wells. It was recently characterized that the small intestine was the main area of uranium absorption throughout the gastrointestinal tract. This study was designed to determine the role played by the Peyer's patches in the intestinal absorption of uranium, as well as the possible accumulation of this radionuclide in lymphoid follicles and the toxicological or pathological consequences on the Peyer's patch function subsequent to the passage and/or accumulation of uranium. Results of experiments performed in Ussing chambers indicate that the apparent permeability to uranium in the intestine was higher (10-fold) in the mucosa than in Peyer's patches ((6.21+/-1.21 to 0.55+/-0.35)x10(-6)cm/s, respectively), demonstrating that the small intestinal epithelium was the preferential pathway for the transmucosal passage of uranium. A quantitative analysis of uranium by ICP-MS following chronic contamination with depleted uranium during 3 or 9 months showed a preferential accumulation of uranium in Peyer's patches (1355% and 1266%, respectively, at 3 and 9 months) as compared with epithelium (890% and 747%, respectively, at 3 and 9 months). Uranium was also detected in the mesenteric lymph nodes ( approximately 5-fold after contamination with DU). The biological effects of this accumulation of depleted uranium after chronic contamination were investigated in Peyer's patches. There was no induction of the apoptosis pathway after chronic DU contamination in Peyer's patches. The results indicate no change in the cytokine expression (Il-10, TGF-beta, IFN-gamma, TNF-alpha, MCP-1) in Peyer's patches and in mesenteric lymph nodes, and no modification in the uptake of yeast cells by Peyer's patches. In conclusion, this study shows that the Peyer's patches were a site of retention for uranium following the chronic ingestion of this radionuclide, without any biological consequences of such accumulation on Peyer's patch functions.

PMID: 16978755


Forget testing for prions, test for uranium in the peyer's patches!
 

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