Cuomo, during an appearance before the Syracuse Post-Standard's editoral board Wednesday, was asked his thoughts on Weiner entering the race.
"He runs? He runs," the paper quotes him as saying in a transcript.
But asked how he would feel if Weiner (self-pictured at right) were to be elected, Cuomo was blunt.
"Shame on us," he replied.
Cuomo, a Democrat, has said he has no plans to get involved in the mayor's race.
He gave a less definitive answer hours before he spoke to the Syracuse paper when asked by reporters in Buffalo for his reaction to Weiner entering the race.
“None,” Cuomo said.
"No reaction. Look, my face didn’t move. No reaction."
The last thing Cuomo probably wants to discuss is the race of a candidate who resigned his congressional seat amid a sexting scandal.
He's spent plenty of time answering questions in recent weeks about the ongoing shenanigans in the state Legislature, including the Vito Lopez sexual harassment case and Assembly Speaker Sheldon Silver's admitted mishandling of it.
At his Syracuse meeting, he was asked about whether the Legislature should limit how long legislative leaders serve. Cuomo reiterated he's against term limits, saying the election process serves that function.
"It's basically democracy," Cuomo said. "Those are grownups (in the Assembly) who are picking, who pick their leader."