SOME interesting aspects of this study ;
These data predict that for human iatrogenic spread of sCJD as a whole, this genotype may be the most susceptible or may show shorter incubation periods. It is of note that there is an increased prevalence of young (<50 y) VV genotype sCJD cases across European countries (United Kingdom, Germany, Italy, and France) (10).
The second common characteristic among the data was that HuMM and HuMV mice had similar levels of clinical disease, and mean incubation periods, for four of the six inocula [excluding sCJD(MM2) and sCJD(VV1)]. This suggests that the methionine allele of PrPC in the heterozygous HuMV mice may have had a dominant effect over the valine allele PrPC with regard to the transmission properties. This study identifies two areas of risk in terms of developing sCJD. The first is that the highest risk of developing CJD after exposure to infection is from strain M1CJD [sCJD(MM1) or sCJD(MV1)] and that the VV genotype confers the highest risk of acquiring infection. The epidemiological findings in sCJD demonstrate that approximately 80% of patients are diagnosed with “classic CJD” types MM1 and MV1, which might intriguingly suggest an infectious rather than genetic origin for the majority of sCJD cases.
snip...
Therefore if sCJD(MV2) and sCJD(VV2) were to become iatrogenic sources of human infection, the host response may be indistinguishable from sCJD(MM1) and more transmissible with respect to further infection.
END...TSS
Wednesday, June 16, 2010
Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties
http://creutzfeldt-jakob-disease.blogspot.com/2010/06/defining-sporadic-creutzfeldt-jakob.html
These data predict that for human iatrogenic spread of sCJD as a whole, this genotype may be the most susceptible or may show shorter incubation periods. It is of note that there is an increased prevalence of young (<50 y) VV genotype sCJD cases across European countries (United Kingdom, Germany, Italy, and France) (10).
The second common characteristic among the data was that HuMM and HuMV mice had similar levels of clinical disease, and mean incubation periods, for four of the six inocula [excluding sCJD(MM2) and sCJD(VV1)]. This suggests that the methionine allele of PrPC in the heterozygous HuMV mice may have had a dominant effect over the valine allele PrPC with regard to the transmission properties. This study identifies two areas of risk in terms of developing sCJD. The first is that the highest risk of developing CJD after exposure to infection is from strain M1CJD [sCJD(MM1) or sCJD(MV1)] and that the VV genotype confers the highest risk of acquiring infection. The epidemiological findings in sCJD demonstrate that approximately 80% of patients are diagnosed with “classic CJD” types MM1 and MV1, which might intriguingly suggest an infectious rather than genetic origin for the majority of sCJD cases.
snip...
Therefore if sCJD(MV2) and sCJD(VV2) were to become iatrogenic sources of human infection, the host response may be indistinguishable from sCJD(MM1) and more transmissible with respect to further infection.
END...TSS
Wednesday, June 16, 2010
Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties
http://creutzfeldt-jakob-disease.blogspot.com/2010/06/defining-sporadic-creutzfeldt-jakob.html