It doesn't look like the Dems will get 60 seats in the Senate this time. But another Republican is not running again in 2010. So there's hope for 60 then.
A bit more about who might run for the seat here: http://miamiherald.typepad.com/nakedpolitics/2008/12/martinez-not-se.html
Martinez not seeking re-election
U.S. Sen. Mel Martinez will announce at 11 a.m. today that he will not seek re-election, setting off a free-for-all over an open Senate seat in 2010.
A bit more about who might run for the seat here: http://miamiherald.typepad.com/nakedpolitics/2008/12/martinez-not-se.html