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Prion diseases are efficiently transmitted by blood transf..

flounder

Well-known member
Submitted April 18, 2008 Accepted June 28, 2008

Prion diseases are efficiently transmitted by blood transfusion in sheep

Fiona Houston*, Sandra McCutcheon, Wilfred Goldmann, Angela Chong, James Foster, Silvia Siso, Lorenzo Gonzalez, Martin Jeffrey, and Nora Hunter Division of Animal Production and Public Health, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom Neuropathogenesis Division, Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom Veterinary Laboratories Agency, Lasswade Laboratory, Edinburgh, United Kingdom

* Corresponding author; email: [email protected]

The emergence of variant Creutzfeld-Jakob disease (vCJD), following on from the bovine spongiform encephalopathy (BSE) epidemic, led to concerns about the potential risk of iatrogenic transmission of disease by blood transfusion and the introduction of costly control measures to protect blood supplies. We previously reported preliminary data demonstrating the transmission of BSE and natural scrapie by blood transfusion in sheep. The final results of this experiment, reported here, give unexpectedly high transmission rates by transfusion of 36% for BSE and 43% for scrapie. A proportion of BSE-infected tranfusion recipients (3/8) survived for up to 7 years without showing clinical signs of disease. The majority of transmissions resulted from blood collected from donors at >50% of the estimated incubation period. The high transmission rates and relatively short and consistent incubation periods in clinically positive recipients suggest that infectivity titres in blood were substantial and/or that blood transfusion is an efficient method of transmission. This experiment has established the value of using sheep as a model for studying transmission of vCJD by blood products in humans.

http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2008-04-152520v1


Greetings again Dr. Freas et al at FDA,

THIS was like closing the barn door after the mad cows got loose. not only the red cross, but the FDA has failed the public in protecting them from the TSE aka mad cow agent. TSE agent i.e. bse, base, cwd, scrapie, tme, and any sub strains thereof. we do not know if these strains will or have transmitted to humans as subclinical TSE or clinical disease, and we do not know if they have or will transmit second, third, forth passage via friendly fire i.e. multiple potential routes via medical, surgical, pharmaceutical etc. ...


for any still interested ;


Thursday, July 24, 2008

Prion diseases are efficiently transmitted by blood transfusion in sheep

Submitted April 18, 2008 Accepted June 28, 2008

http://vcjdblood.blogspot.com/2008/07/prion-diseases-are-efficiently.html


as i recall, blood is still allowed as a feed additive. ...tss
 

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