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The first Japanese patient with vCJD Case Report

flounder

Well-known member
----- Original Message -----
From: "Terry S. Singeltary Sr." <[email protected]>
To: <[email protected]>
Sent: Monday, April 27, 2009 2:51 PM
Subject: [CJD-L] The first Japanese patient with variant Creutzfeldt-Jakob
disease (vCJD) Case Report


Case Report

The first Japanese patient with variant Creutzfeldt-Jakob disease (vCJD)

Akiyo Shinde, 1 Takenobu Kunieda, 1 Yoshimi Kinoshita, 1 Reika Wate, 1
Satoshi Nakano, 1 Hidefumi Ito, 1 Masahito Yamada, 2 Tetsuyuki Kitamoto, 3
Yosikazu Nakamura, 4 Sadayuki Matsumoto 5 and Hirofumi Kusaka 1 1 Department
of Neurology, Kansai Medical University, Moriguchi, 2 Department of
Neurology and Neurobiology of Aging, Kanazawa University Graduate School of
Medical Science, Kanazawa, 3 Division of CJD Science and Technology,
Department of Prion Research, Center for Translational and Advanced Animal
Research on Human Diseases, Tohoku University Graduate School of Medicine,
Sendai, 4 Department of Public Health - Inquiry, Jichi Medical University,
Shimotsuke, and 5 Department of Neurology, Kitano Hospital, Osaka, Japan
Correspondence to Akiyo Shinde, md, Department of Neurology, Kansai Medical
University, Fumizono-cho 10-15, Moriguchi 570-8506, Japan. Email:
[email protected] This case was presented in a preliminary form in the
annual meeting of Japanese Neuropathological Association in Tokyo, 2008.

Copyright © 2009 Japanese Society of Neuropathology KEYWORDS latent period .
periodic synchronous discharge . pulvinar sign . spongiform encephalopathy .
variant Creutzfeldt-Jakob disease


ABSTRACT


Eleven years after a brief visit to some European countries, a 48-year-old
Japanese man developed writing difficulty, irritability and general fatigue.
Then he complained of dysesthetic pains in his legs, for which
benzodiazepines were prescribed. However, at the time pulvinar sign was
retrospectively confirmed on brain MRI. Eighteen months after the onset, his
gait became ataxic with rapid deterioration of mental status over the
following several months. Thirty-one months after the onset, he became
akinetic and mute with periodic synchronous discharges on EEG, and died at
the age of 51. The total clinical course was approximately 43 months.
Pathological examination revealed the characteristic alterations of
spongiform encephalopathy, severe in the thalamus, moderate but widely
spread in the cerebral cortices, and moderate in the cerebellum. Abundant
amyloid plaques were easily identified in the cerebral cortex and the
cerebellum on HE staining. Immunohistochemistry for abnormal prion protein
(PrPsc) confirmed amyloid plaques in several forms, such as florid, uni- and
multi-centric plaques as well as perineuronal and periaxonal deposits in the
basal ganglia and synaptic patterns in the thalami. A Western blotting study
identified type 2B protease-resistant PrP. This is the first Japanese
patient who was definitely diagnosed as variant Creutzfeldt-Jakob disease
(vCJD). The pathological findings were similar to those of previous reports
of vCJD in the UK. However, the changes were much more severe both in degree
and distribution, probably due to a longer duration of the illness than
those in the UK.

--------------------------------------------------------------------------------

Received 5 November 2008; revised and accepted 7 January 2009.

DIGITAL OBJECT IDENTIFIER (DOI) 10.1111/j.1440-1789.2009.01006.x About DOI

http://www3.interscience.wiley.com/journal/122241574/abstract?CRETRY=1&SRETRY=0



http://www.ncbi.nlm.nih.gov/pubmed/19389077?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum



----- Original Message -----
From: "TERRY SINGELTARY" <[email protected]>
To: <[email protected]>
Sent: Tuesday, March 10, 2009 9:03 PM
Subject: [BSE-L] JAPAN-Local governments to carry on BSE testing despite
subsidy cuts

-------------------- [email protected] --------------------

11/03/2009 00:54:58

Japan-BSE Testing.

JAPAN-Local governments to carry on BSE testing despite subsidy cuts

Every local government across the country with meat inspection facilities
will continue to test all beef cows for mad cow disease during the next
fiscal year, a Mainichi survey has found.

The finding comes despite the central government's abolition of about 200
million yen in annual subsidies to local governments for bovine spongiform
encephalopathy (BSE) tests. Japan is the only country where all beef cows
are tested for the disease.

In August 2005, the Health, Labor and Welfare Ministry deemed that there is
no need for BSE tests on cows 20 months old or younger, on the grounds that
no cow born before January 2002 has been found infected with BSE and that
there is little chance of finding BSE in such young cows even if they have
been infected.

Nevertheless, the ministry had extended subsidies to local governments
conducting BSE tests on all beef cows until July last year.

Officials in charge at all 77 prefectural and municipal governments that
have beef inspection facilities said they will continue BSE tests on all
beef cows in fiscal 2009.

Among the reasons given was the need to "maintain the brand image of their
locally produced beef" and "prevent confusion in the marketing process."

However, 30 government bodies said that there was no discussion on whether
to continue testing. The survey also suggested that governments tend to
abide by the policy of their peers and requests from local residents.

"It would take a lot of nerve to stop it while other prefectures are
continuing it," said an official at the Akita Prefectural Government.

"We'd like to stop it but we can't gain support from local residents," a
Miyagi Prefectural Government representative said. An official at the
Yokohama Municipal Government said that the national government needs to
take the initiative in convincing the public of the safety of beef.

The Toyohashi Municipal Government in Aichi Prefecture called on the
national government to organize a nationwide BSE testing system. "Since beef
is marketed in widespread areas, there is no point in conducting inspections
on them unless they are coordinated.."

The government has also applied with the World Organization for Animal
Health to raise its evaluation of Japan's BSE countermeasures from the
lowest level of "a country whose BSE risk is unknown" to the middle level of
"a country having a controlled BSE risk.."

Japan filed the application after it was decided to abolish a practice
called "pithing" at all meat treatment centers across the country by the end
of this fiscal year. In pithing, a wire is inserted into the cow's head to
destroy the brains and spinal marrow and to prevent them from thrashing
around. The practice is feared to raise the risk of BSE infections.

The government expects its application to be approved at a general meeting
of the organization to be held in May this year.


http://www.farminguk.com/news/Japan-BSE-Testing.12958.asp



I applaud Japans effort to continue to try and eradicate BSE (TSE) i.e. mad
cow from their herds. A far cry as to what the USDA has done here in the
USA. they did just the opposite. the truth hurts sometimes when reality sets
in $$$

WITHOUT a doubt, IF the USA, Canada, and Mexico can have a terribly flawed
favorable rating, even though they are BSE GBR risk factor III, and even at
that it was on flawed data, with all this, why not Japan being as controlled
as the USA and North America ??? it's all about money is it not $$$ that's
what Prusiner et al told the hearing committee in California ;

DAMNING TESTIMONY FROM STANLEY PRUSINER THE NOBEL PEACE PRIZE WINNER ON
PRIONS SPEAKING ABOUT ANN VENEMAN

''they don't wanna know, the dont' care''


http://maddeer.org/video/embedded/prusinerclip.html



----- Original Message -----

From: TERRY SINGELTARY
To: [email protected]
Cc:
Sent: Friday, March 06, 2009 4:27 PM
Subject: Risk of Introduction of BSE into Japan by the Historical
Importation of Live Cattle from the United Kingdom

Journal of Veterinary Medical Science

Vol. 71 (2009) , No. 2 February pp.133-138

Risk of Introduction of BSE into Japan by the Historical Importation of Live
Cattle from the United Kingdom

Katsuaki SUGIURA1), Toyoko KUSAMA1), Tomotaro YOSHIDA1), Naoki SHINODA1) and
Takashi ONODERA2)

1) Food and Agricultural Materials Inspection Center 2) Department of
Molecular Immunology, University of Tokyo

(Received 10-Mar-2008) (Accepted 3-Sep-2008)

ABSTRACT. All cattle imported from the United Kingdom to Japan since 1980
and slaughtered before 2002 were traced (n=33), and the number of cattle
that were possibly infected with BSE and entered the animal feed chain was
calculated. Because there was no effective system to avoid recycling of the
BSE agent via animal feed until the early 1990s, of the 33 cattle imported
from the UK into Japan, most probably 7 or 8 were infected and entered the
animal feed chain, 2 of which entered the animal feed chain in each of 1992
and 1993. In terms of infectivity, 400-550 cattle oral ID50 of the BSE agent
entered the feed chain in each of these years. The amount of infectivity
that entered the feed chain in 1989, 1991 and 1995 was smaller but still
substantial, suggesting that the BSE agent might have entered the Japanese
feed chain in any of these years.

KEY WORDS: bovine spongiform encephalopathy (BSE), import risk analysis,
Japan, live cattle, simulation

snip...


http://www.jstage.jst.go.jp/article/jvms/71/2/133/_pdf


REFERENCES


http://www.jstage.jst.go.jp/article/jvms/71/2/71_133/_cit


Greetings BSE-L members !

Because there was no effective system to avoid recycling of the BSE agent
via animal feed until the early 1990s, of the 33 cattle imported from the UK
into Japan, most probably 7 or 8 were infected and entered the animal feed
chain, 2 of which entered the animal feed chain in each of 1992 and 1993. In
terms of infectivity, 400-550 cattle oral ID50 of the BSE agent entered the
feed chain in each of these years. The amount of infectivity that entered
the feed chain in 1989, 1991 and 1995 was smaller but still substantial,
suggesting that the BSE agent might have entered the Japanese feed chain in
any of these years.<<<

O.K., lets look at other imports of live catte from the U.K. to the U.S.A.
and Canada, just to compare to Japan.

UK Exports of Live Cattle by Value 1986-96

USA 697 LIVE CATTLE

CANADA 299 LIVE CATTLE

SO, where does that leave us here in North America ???

HERE IN THE U.S.A. IT'S WHAT I CALL, MAD COW DENIAL $$$

TSS

USA AND CANADA IMPORTS OF UK CATTLE BETWEEN 1981 - 1989

USA = 496

CANADA = 198

*add 14 to 198 as last UK import to Canada, 14 in 1990


http://www.inspection.gc.ca/english/sci/ahra/bseris/bserise.pdf


HERE is another look at all the imports for both the USA and Canada of UK
live cattle and greaves exports ;

UK Exports of Live Cattle by Value 1986-96

USA 697 LIVE CATTLE

CANADA 299 LIVE CATTLE


http://www.bseinquiry.gov.uk/files/mb/m11f/tab11.pdf


UK EXPORTS OF MBM TO WORLD


http://www.bseinquiry.gov.uk/files/mb/m11g/tab05.pdf


OTHERS


SNIP...

*** SEE FULL TEXT ;


Risk of Introduction of BSE into Japan by the Historical Importation of Live
Cattle from the United Kingdom


http://bseusa.blogspot.com/2009/03/risk-of-introduction-of-bse-into-japan.html


SEE FULL TEXT HERE ;

Tuesday, March 10, 2009

JAPAN-Local governments to carry on BSE testing despite subsidy cuts


http://madcowtesting.blogspot.com/2009/03/japan-local-governments-to-carry-on-bse.html


TSS


The first Japanese patient with variant Creutzfeldt-Jakob disease (vCJD)
Case Report


http://cjdusa.blogspot.com/2009/04/first-japanese-patient-with-variant.html



Monday, April 20, 2009


National Prion Disease Pathology Surveillance Center Cases Examined1
(December 31, 2008)


http://prionunitusaupdate2008.blogspot.com/2009/04/national-prion-disease-pathology.html



Sunday, April 12, 2009

r-calf and the USA mad cow problem, don't look, don't find, and then blame
Canada



http://prionunitusaupdate2008.blogspot.com/2009/04/r-calf-and-usa-mad-cow-problem-dont.html


Docket Management Docket: 02N-0276 - Bioterrorism Preparedness; Registration
of Food Facilities, Section 305 Comment Number: EC -254 Accepted - Volume 11

2003-04-08 10:36:55



http://www.fda.gov/OHRMS/DOCKETS/DOCKETS/02n0276/02N-0276-EC-254.htm



http://madcowfeed.blogspot.com/2008/07/docket-aphis-2007-0033-docket-title.html




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