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Transcriptional changes of cattle orally infected with BSE

flounder

Well-known member
J. Virol. doi:10.1128/JVI.00352-09 Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Transcriptional changes in the brain of cattle orally infected with BSE precede detection of infectivity

Yue Tang, Wei Xiang, Steve A.C. Hawkins, Hans A. Kretzschmar, and Otto Windl* Department of Molecular Pathogenesis and Genetics and Department of Pathology, Veterinary Laboratories Agency, Woodham Lane, New Haw, Surrey KT15 3NB, UK; Institute of Neuropathology, Ludwig-Maximilians-University Munich, Munich, Germany

* To whom correspondence should be addressed. Email: [email protected]

Abstract

Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. BSE can be transmitted experimentally between cattle through the oral route and in this study brain tissue samples from animals at different time points post inoculation were analysed for changes in gene expression. The aims of this study were to identify differentially regulated genes during the progression of BSE using microarray based gene expression profiling and to understand the effect of prion pathogenesis on gene expression. A total of 114 genes were found to be differentially regulated over the time course of the infection and many of these 114 genes encode proteins involved in immune response, apoptosis, cell adhesion, stress response and transcription. This study also revealed a broad correlation between gene expression profiles and the progression of BSE in cattle. At 21 months post inoculation, the largest number of differentially regulated genes was detected, suggesting that there are many pathogenic processes in the animal brain even prior to the detection of infectivity in the CNS of these orally dosed cattle. Moreover, evidence is presented to suggest that it is possible to predict the infectious status of animals using the expression profiles from this study.



http://jvi.asm.org/cgi/content/abstract/JVI.00352-09v1?etoc



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Terry S. Singeltary Sr.

P.O. Box 42

Bacliff, Texas USA 77518



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Transcriptional changes in the brain of cattle orally infected with BSE precede detection of infectivity

J. Virol. doi:10.1128/JVI.00352-09 Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.



http://madcowspontaneousnot.blogspot.com/2009/07/transcriptional-changes-in-brain-of.html
 

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