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USA hiding reseach about animal retention of radionuclides.

Kathy

Well-known member
First, an interesting review (from 1989) on USA research on radioacitve contamination of animals, for which the author states - "Also, much of the data are in internal reports that are not easily accessible. In-depth reviews of work done in the U.S. are not available." I wonder why this info is worth hiding?

Followed by new information on absorption and retention of radionuclides and metals in rats, with a copper connection; read away.

Sci Total Environ. 1989 Sep;85:1-15.

Transfer of radionuclides to animals--an historical perspective of work done in the United States.

Richmond CR. Oak Ridge National Laboratory, Tennessee 37831-6253.

This report presents a historical perspective of work done in the U.S. on the metabolism of radionuclides by animals. Also covered are the important concepts of interspecies metabolic correlations and means of accelerating turnover of internally deposited radionuclides. Although a large amount of data exist for a large number of radionuclides and animal species there are many parameters of interest and additional data is needed. Also, much of the data are in internal reports that are not easily accessible. In-depth reviews of work done in the U.S. are not available. If I were asked for recommendations following this workshop, I would propose the formation of a committee to comprehensively review the available data on the metabolism of radionuclides by animals and, if necessary, to plan work that could be conducted by multinational teams of scientists. The results of the planned experiments would remove the remaining uncertainties associated with the uptake, retention and loss of radionuclides by animals that are of economic importance, primarily as food sources, to man. The data would also provide the necessary input to other international efforts related to the calculation of radiation dose per unit intake for members of the general public. These kinds of joint international studies are common in the physical sciences. More are needed in the biological sciences. In addition, this is truly a global problem requiring international collaboration and cooperation. The sharing of the burden would help ensure the collection of the necessary data in a timely and cost effective manner.

PMID: 2683066

Biol Trace Elem Res. 1989 Jul-Sep;21:213-8.

Gut retention of metals in rats.

Kostial K, Kargacin B, Landeka M.
Institute for Medical Research and Occupational Health, University of Zagreb, Yugoslavia.

In sucklings, a high fraction of orally administered metals and radionuclides is retained in the gut. The location of elements in the gut is of interest because of their potential local health effect. The purpose of this work was to evaluate the influence of chelation therapy on gut retention and location of cadmium, mercury, and cerium in suckling rats. Radionuclides 115mCd, 203Hg, and 141Ce were administered orally to 6-d-old rats. Chelating agent Zn-DTPA (3.64 mmol/kg) was administered to animals that received 115mCd or 141Ce and Na-DMPS (375 mumols/kg) to those that received 203Hg, immediately and 24 h or 24 and 48 h after radionuclide administration. Radioactivity was determined in the whole body and gastrointestinal tract 6 d later. Both early and delayed chelation treatment very effectively reduced whole body retention, and this was mainly owing to reduced gut retention. Although chelation therapy reduced gut retention of administered radionuclides 3-30 times, the site of metal accumulation and retention in the intestine remained unchanged. For all 3 radionuclides, both after early and delayed therapy, the site of metal accumulation was always the lower part of small intestine-ileum.

PMID: 2484589

Better known as the distal ileum, which is considered a
specified risk material, or SRM.


I'd like to draw your attention to this new study, in a series of studies on the absorption and retention of radionuclides in rats, including Depleted Uranium. Note: no abstract is available, however, the Entrez Pubmed search engine lists the top related links, the first two of which are referring to the "retention, absorption and homeostasis" of COPPER.

Ann ICRP. 2006;36(1-2):233-86. Links

Annex D: absorption and retention of radionuclides.

Paquet F, Harrison JD. PMID: 17188194
(No Abstract available.)

Related Links:

Long-term high copper intake: effects on copper absorption, retention, and homeostasis in men. [Am J Clin Nutr. 2005] PMID: 15817858

Copper absorption and retention in young men at three levels of dietary copper by use of the stable isotope 65Cu. [Am J Clin Nutr. 1989] PMID: 2718922

Accumulation of radionuclides by plants as a monitor system. [Environ Health Perspect. 1978] PMID: 367767

Implications of airway retention for radiation doses from inhaled radionuclides. [J Aerosol Med. 1995] PMID: 10172643

Effects of porcine sometotropin on calcium and phosphorus balance and markers of bone metabolism in finishing pigs. [J Anim Sci. 1999] PMID: 10461995

Gut retention of metals in rats. (see above)
 
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