As far as brisket is concerned, I first select a well-marbled one and DON"T trim it! As I said before, I have never found a better way to fix brisket than in a covered pan and cooked on low for 4 to 6 hours depending on the size. I never add any broth! Slow cooking in its own juices is the secret to flavor.
I cut my brisket to 2-3" thick and use a deep pan. I season it only with salt and pepper or sometimes a favorite STEAK seasoning salt. It gets so tender it just falls apart. For chili, I use a very deep skillet and I take it out after an hour and then cut it into 1/2" cubes then put it back into the skillet and its own juices, and then add the other chili ingredients.
Slow smoking just dries out brisket and all the flavor is going down into the grease pan. If a method of cooking requires slathering on heavy BBQ sauce, then it is my opinion that you just lost all the natural flavor of the beef and might as well be slathering up a piece of tofu with Famous Dave's BBQ sauce while wearing flowers in your hair and singing The Eve of Destruction. I had rather spend an evening with the Hindu eating okra boiled in hot curry sauce.

