Kathy
Well-known member
Take some time to read a new paper by Dr. Adriano Aguzzi entitled,
"Repetitive Immunization Enhances the Susceptibility of Mice to Peripherally Administered Prions". (free on-line)
Mice were given injections of CpG oligodeoxynucleotides, followed by bovine serum albumin and ALUM injections. These mice experienced increased susceptibility to intraperitoneal injections of RML brain homogenate.
Evidence is starting to narrow down to something we discussed back in 2006, ie: the concentration of metals in the lysosomes, their effects on immune responses etc.
Cell Mol Biol (Noisy-le-grand). 1996 May;42(3):395-411. Links
The role of lysosomes in the selective concentration of mineral elements. A microanalytical study.
Berry JP.
Laboratoire de Biophysique, S.C. 27 de 1'INSERM, Faculté de Médecine, Créteil, France.
The role of the lysosome during the intracellular concentration of diverse mineral elements has been evidenced by the electron probe X-ray microanalysis (EPMA). This highly sensitive technique allows an in situ chemical analysis of any chemical element with an atomic number greater than 11, present in ultra-thin tissue sections. Therefore, it has been demonstrated by using this EPMA that 21 out of the 92 elements of the periodic table, once injected in a soluble form, were selectively concentrated within lysosomes of several types of mammalian cells. Amongst these 21 elements, 15 are concentrated and precipitated in an insoluble from in association with phosphorus whereas the other 6 are precipitated in association with sulphur. Amongst the 15 elements which precipitate with phosphorus in lysosomes, there are: 3 group IIIB elements of the periodic system, (aluminium, gallium and indium); the rare-earth elements (cerium, gadolinium, lanthanum, thulium and samarium); 2 group IVA elements (hafnium and zirconium), two actinides (uranium and thorium) and elements such as chromium and niobium. The 6 elements which precipitate with sulphur comprise the 3 group VIII elements of the classification (nickel, palladium, platinum) and the 3 group IB elements (copper, silver and gold). The mechanisms responsible for this selective concentration involve enzymatic processes and predominantly acid phosphatases for elements precipitating as phosphates and arylsulfatases for elements precipitating with sulphur.
PMID: 8793193
Microsc Res Tech. 1997 Feb 15;36(4):313-23. Links
Role of alveolar macrophage lysosomes in metal detoxification.
Berry JP, Zhang L, Galle P, Ansoborlo E, Hengé-Napoli MH, Donnadieu-Claraz M.
Laboratoire de Biophysique-SC 27 INSERM, Faculté de Médecine Créteil.
The intracellular behaviour of different toxic mineral elements inhaled as soluble aerosols or as insoluble particles was studied in the rat by electron microscopy, electron probe microanalysis, and electron microdiffraction. This study showed that, after inhalation, aerosols of soluble elements like cerous chloride, chromic chloride, uranyl nitrate, and aluminium chloride, are concentrated in the lysosomes of alveolar macrophages and are precipitated in the lysosomes in the form of insoluble phosphate, probably due to the activity of acid phosphatase (intralysosomial enzyme). Also, after inhalation of crystalline particles that are insoluble or poorly soluble in water such as the illites (phyllosilicates), ceric oxides (opaline), and industrial uranium oxides (U3O8), the small crystals are captured by the alveolar macrophage lysosomes and transformed over time into an amorphous form. This structural transformation is associated with changes in the chemical nature of particles inhaled in the oxide form. Microanalysis of amorphous deposits observed after inhalation of uranium or ceric oxides has shown that they contain high concentrations of phosphorus associated with the initial elements cerium and uranium. These different processes tend to limit the diffusion of these toxic elements within the organism, whether they are inhaled in soluble form or not.
PMID: 9140931
Joshua HAmilton at MBL and Dartmouth Medical School also found that exposure to aresenic resulted problems dealing with the H1N1 virus;
"However, in mice that had ingested 100 ppb arsenic in their drinking water for five weeks, the immune response to H1N1 infection was initially feeble and when a response finally did kick in days later, it was "too robust and too late". "There was a massive infiltration of immune cells to the lungs and a massive inflammatory response, which led to bleeding and damage in the lung." Morbidity over the course of the infection was significantly higher for the arsenic-exposed animals than the normal animals.
http://www.eurekalert.org.pub_release/2009-05/mbl-sli052009.php
The connecting thread here, is what is happening in the cells responsible for debris clean-up and immune responses.... What happens when the lysosomes are filled with these various metals that apparently accumulate there.
Chickens are often fed arsenic to kill bacteria and bugs in their systems. Fertilized chicken eggs are used to grow the flu vaccines. Vaccines contain aluminum adjuvants including AAHS "amorphous aluminum hydroxyphosphate sulfate".
The prion research shows that the "injections" or as they like to call them "immunizations" resulted in only the immunized mice being more susceptible to moderate levels of scrapie i.p.
The disturbance of the immune system by the bovine serum and ALUM somehow aided in the disease progression.
Arsenic did the trick for H1N1, yet copper is said to be able to destroy H1N1 (google it).
"Repetitive Immunization Enhances the Susceptibility of Mice to Peripherally Administered Prions". (free on-line)
Mice were given injections of CpG oligodeoxynucleotides, followed by bovine serum albumin and ALUM injections. These mice experienced increased susceptibility to intraperitoneal injections of RML brain homogenate.
Evidence is starting to narrow down to something we discussed back in 2006, ie: the concentration of metals in the lysosomes, their effects on immune responses etc.
Cell Mol Biol (Noisy-le-grand). 1996 May;42(3):395-411. Links
The role of lysosomes in the selective concentration of mineral elements. A microanalytical study.
Berry JP.
Laboratoire de Biophysique, S.C. 27 de 1'INSERM, Faculté de Médecine, Créteil, France.
The role of the lysosome during the intracellular concentration of diverse mineral elements has been evidenced by the electron probe X-ray microanalysis (EPMA). This highly sensitive technique allows an in situ chemical analysis of any chemical element with an atomic number greater than 11, present in ultra-thin tissue sections. Therefore, it has been demonstrated by using this EPMA that 21 out of the 92 elements of the periodic table, once injected in a soluble form, were selectively concentrated within lysosomes of several types of mammalian cells. Amongst these 21 elements, 15 are concentrated and precipitated in an insoluble from in association with phosphorus whereas the other 6 are precipitated in association with sulphur. Amongst the 15 elements which precipitate with phosphorus in lysosomes, there are: 3 group IIIB elements of the periodic system, (aluminium, gallium and indium); the rare-earth elements (cerium, gadolinium, lanthanum, thulium and samarium); 2 group IVA elements (hafnium and zirconium), two actinides (uranium and thorium) and elements such as chromium and niobium. The 6 elements which precipitate with sulphur comprise the 3 group VIII elements of the classification (nickel, palladium, platinum) and the 3 group IB elements (copper, silver and gold). The mechanisms responsible for this selective concentration involve enzymatic processes and predominantly acid phosphatases for elements precipitating as phosphates and arylsulfatases for elements precipitating with sulphur.
PMID: 8793193
Microsc Res Tech. 1997 Feb 15;36(4):313-23. Links
Role of alveolar macrophage lysosomes in metal detoxification.
Berry JP, Zhang L, Galle P, Ansoborlo E, Hengé-Napoli MH, Donnadieu-Claraz M.
Laboratoire de Biophysique-SC 27 INSERM, Faculté de Médecine Créteil.
The intracellular behaviour of different toxic mineral elements inhaled as soluble aerosols or as insoluble particles was studied in the rat by electron microscopy, electron probe microanalysis, and electron microdiffraction. This study showed that, after inhalation, aerosols of soluble elements like cerous chloride, chromic chloride, uranyl nitrate, and aluminium chloride, are concentrated in the lysosomes of alveolar macrophages and are precipitated in the lysosomes in the form of insoluble phosphate, probably due to the activity of acid phosphatase (intralysosomial enzyme). Also, after inhalation of crystalline particles that are insoluble or poorly soluble in water such as the illites (phyllosilicates), ceric oxides (opaline), and industrial uranium oxides (U3O8), the small crystals are captured by the alveolar macrophage lysosomes and transformed over time into an amorphous form. This structural transformation is associated with changes in the chemical nature of particles inhaled in the oxide form. Microanalysis of amorphous deposits observed after inhalation of uranium or ceric oxides has shown that they contain high concentrations of phosphorus associated with the initial elements cerium and uranium. These different processes tend to limit the diffusion of these toxic elements within the organism, whether they are inhaled in soluble form or not.
PMID: 9140931
Joshua HAmilton at MBL and Dartmouth Medical School also found that exposure to aresenic resulted problems dealing with the H1N1 virus;
"However, in mice that had ingested 100 ppb arsenic in their drinking water for five weeks, the immune response to H1N1 infection was initially feeble and when a response finally did kick in days later, it was "too robust and too late". "There was a massive infiltration of immune cells to the lungs and a massive inflammatory response, which led to bleeding and damage in the lung." Morbidity over the course of the infection was significantly higher for the arsenic-exposed animals than the normal animals.
http://www.eurekalert.org.pub_release/2009-05/mbl-sli052009.php
The connecting thread here, is what is happening in the cells responsible for debris clean-up and immune responses.... What happens when the lysosomes are filled with these various metals that apparently accumulate there.
Chickens are often fed arsenic to kill bacteria and bugs in their systems. Fertilized chicken eggs are used to grow the flu vaccines. Vaccines contain aluminum adjuvants including AAHS "amorphous aluminum hydroxyphosphate sulfate".
The prion research shows that the "injections" or as they like to call them "immunizations" resulted in only the immunized mice being more susceptible to moderate levels of scrapie i.p.
The disturbance of the immune system by the bovine serum and ALUM somehow aided in the disease progression.
Arsenic did the trick for H1N1, yet copper is said to be able to destroy H1N1 (google it).