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Antibotic use in Agriculture production

E. de Boera, Corresponding Author Contact Information, E-mail The Corresponding Author, J.T.M. Zwartkruis-Nahuisa, B. Wita, X.W. Huijsdensc, A.J. de Neelingc, T. Boschc, R.A.A. van Oosteromb, A. Vilaa and A.E. Heuvelinka

aFood and Consumer Product Safety Authority (VWA), PO Box 202, 7200 AE Zutphen, The Netherlands

bFood and Consumer Product Safety Authority (VWA), PO Box 19506, 2500 CM Den Haag, The Netherlands

cNational Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands
Received 13 August 2008;
revised 18 November 2008;
accepted 7 December 2008.
Available online 13 December 2008.

Abstract

Recently the isolation of methicillin-resistant Staphylococcus aureus (MRSA) strains from several food-producing animals has been reported. During slaughtering of MRSA-positive animals, contamination of carcasses with MRSA may occur and consequently the meat of these animals may get contaminated. The aim of this study was to estimate the prevalence of MRSA in raw meat samples from the retail trade.

Samples of raw beef, pork, veal, lamb/mutton, chicken, turkey, fowl and game were collected from the retail trade. A detection method including a two-step enrichment in Mueller–Hinton broth + 6.5% NaCl and phenol red mannitol broth containing ceftizoxime and aztreonam, followed by isolation on MRSA ID agar (bioMérieux) was evaluated and subsequently applied for the detection of MRSA in samples of raw meats.

MRSA strains were isolated from 264 (11.9%) of 2217 samples analyzed. Isolation percentages for the meat species were: beef (10.6%), veal (15.2%), lamb and mutton (6.2%), pork (10.7%), chicken (16.0%), turkey (35.3%), fowl (3.4%) and game (2.2%). The majority (85%) of the isolated strains belonged to spa-types of pulsed-field gel electrophoresis (PFGE) non-typeable (NT)-MRSA, corresponding to the multilocus sequence type ST398, a type also recently isolated in the Netherlands from pigs. However, a smaller part of these strains were found to be of other ST's, possibly of human origin.

Further studies are needed to elucidate transmission routes of MRSA in relation to meat and other foods and to provide the tools for preventing the spread of MRSA. At present the high prevalence of MRSA in meat has not been shown to contribute significantly to the dissemination of MRSA to humans and the possible health hazard for consumers of the presence of MRSA in foods should be further elucidated.

Keywords: MRSA; Meat; MLST; spa-Typing




http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7K-4V4KPK5-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dbbf3464864ee7ab3b9b29329f66a781

http://www.iatp.org/iatp/publications.cfm?refid=107139


Flouroquinolones were used extensively in poultry. I think some of that has been curbed.


On a personal note, my kid has (as of 2 or 3 weeks ago) MRSA staph and is working to get rid of it. There are some drugs that can treat it and in our case quite well, but the doctor had to take samples to see what medication was most effective. Clorox baths to get rid of any colonization on the skin.

My kid seems to be doing fine but it is scary that there are limited treatments after these antibiotics are used. This is a disease that eats through your skin and deep into your body. It can eventually kill you.

Tex
 
USDA's FSIS meat inspection enforcement is steping up residue tests after FDA told them to start testing more often as the reports are picking up.


"Warning Letter" to Crestview Calves Inc. in Hazelton, Idaho, over a calf sold on Aug. 14, 2009 that was found by the U.S. Department of Agriculture's Food Safety and Inspection Service to have unacceptable levels of gentamicin sulfate.

FDA has a zero tolerance level for gentamicin sulfate. Its investigation found Crestview is not using the new animal drug as directed by the veterinarian's prescription.

Across the country, in South Solon, Ohio, the Stardust Dairy received a similar letter. The only difference was the cow it sold on April 20, 2009 was found by FSIS to have a higher than tolerated level of the animal drug flunixin.

Flunixin is a non-steroidal anti-inflammatory drug more properly used to treat horses.

Companies have only 15 working days to respond to a "Warning Letter."
 
Flunixin is a non-steroidal anti-inflammatory drug more properly used to treat horses.
Banamine? Resflor Gold? Both contain flunixin. Both are labeled for cattle.
 
Texan said:
Flunixin is a non-steroidal anti-inflammatory drug more properly used to treat horses.
Banamine? Resflor Gold? Both contain flunixin. Both are labeled for cattle.

I don't know exactly, Texan, but the cases cited could be because of lack of withdrawel time before slaughter.

Tex
 
Tex said:
Texan said:
Flunixin is a non-steroidal anti-inflammatory drug more properly used to treat horses.
Banamine? Resflor Gold? Both contain flunixin. Both are labeled for cattle.

I don't know exactly, Texan, but the cases cited could be because of lack of withdrawel time before slaughter.

Tex
I'm sure you're probably right about that, Tex. I just wanted to point out that the article posted some misinformation. But you're right about the withdrawals and it seems to be a common practice among dairymen to ignore them. We can never underestimate the abilities of dairymen to screw things up in the name of all beef producers.
 
Judge Orders NY Dairy to Stop Selling Cows

by Dan Flynn |Food safety News Mar 27, 2010

A Wyoming, New York dairy farmer was ordered to stop selling cows for slaughter until he complies with federal law.

U.S. District Court Judge Richard J. Arcara ordered Jerald P. Schumacher, who sells dairy cattle through an auction yard in Pavilion, NY to be slaughtered for human consumption, to cease doing business. The U.S. Food and Drug Administration cited a sole proprietor of the dairy farm, Schumacher, for selling cows that tested positive for illegal residues of antibiotics.

Judge Arcara, who was appointed to the federal bench by former President Ronald Reagan, signed a consent degree of permanent injunction on March 25, ending Schumacher's ability to sell cows for human consumption.

The FDA complaint said Schumacher has sold cows for slaughter for at least 10 years with residues of the antibiotics penicillin and sulfadimethoxine in the animals' edible tissue. The agency also said he illegally gave the cows higher-than-allowed dosages.

"The sale of animals for animal-derived human food products that contain illegal levels of animal drugs poses a significant public health risk," said Dr. Bernadette Dunham, D.V.M., director of FDA's Center for Veterinary Medicine. "FDA will continue to take action against producers who violate federal laws intended to protect the health of the public and of livestock."

The farm was most recently inspected between Oct. 6 and Oct. 21, 2009, and Schumacher was given a written report detailing the violations. After FDA issued a warning letter in 2006 requiring him to abide by the law, violations continued.

The U.S. Department of Agriculture, which has the responsibility for detecting drug residues in beef sold for human consumption, cited Schumacher six times in the past 10 years.

Schumacher also violated the law by failing to keep adequate records of which cows were medicated, according to the complaint.

FDA routinely finds dairy farmers who are selling cows for human consumption that have higher than allowed levels of animal drugs in edible tissues. On March 8, or example, FDA issued a warning letter to the Double B. Dairy, LLC in Wendell, ID for selling an animal for human consumption that had higher than allowed levels of the drug Flunixin in its system.
Tags: antibiotics
Discuss (2) Share
DiscussHarry Hamil
03/27/2010
7:39AM Dan, I find it interesting that we are seeing case after case of dawdling regulators like this finally getting around to doing their jobs and food safety advocates use it as an argument for MORE regulation.

A quick web search shows the wide press coverage this event has gotten showing the FDA in action. It appears to be doing its job.

How about calling for the enforcement of existing regulations?

How about accountability for those regulators that have allowed this to go on for so long?

Instead we hear about how underfunded the FDA is and excuse them.

Food safety will NOT improve materially in this country until the food safety advocates give up their cozy relationship with the regulators, demand that the regulators do their jobs and hold the inspectors and their bosses accountable when they don't.

When will you write that editorial, Dan?
Doc Mudd
03/28/2010
6:27AM *
"...a sole proprietor of the dairy farm, Schumacher... selling cows that tested positive for illegal residues of antibiotics".
*
Hmmm... it turns out to be a small family farmer, not a sinister 'factory farm' chronically and deliberately abusing antibiotics during the past 10 years!
.
Activists would have me believe that only dreadful 'large corporate farms' are capable of such irresponsible behavior, that small mom and pop operations are pure; no inspections or testing necessary for the little local guys. "Buy Local" and "Know Your Farmer" -- sure, good luck with that!
 
1008 Grinstead Mill Road Dairy

Department of Health and Human Services Public Health Service Food and Drug Administration

March 15, 2010

VIA FEDERAL EXPRESS

WARNING LETTER 10-89924-08

Mr. Kelly Poynter, Sr., Owner 1008 Grinstead Mill Road Cave City, Kentucky 42127-9601

Dear Mr. Poynter:

On October 6, 7, 8, 13, and 14, 2009, the U.S. Food and Drug Administration (FDA) conducted an investigation of your dairy operation located at 1008 Grinstead Mill Road, Cave City, Kentucky 42127-9601. This letter notifies you of the violations of the Federal Food, Drug, and Cosmetic Act (the Act) that we found during our investigation of your operation. You can find the Act and its associated regulations on the Internet through links on FDA's web page at www.fda.gov.

We found that you offered for sale an animal for slaughter as food that was adulterated. Under section 402(a)(2)(C)(ii) of the Act, 21 U.S.C. 342(a)(2)(C)(ii), a food is deemed to be adulterated if it bears or contains a new animal drug that is unsafe under section 512 of the Act, 21 U.S.C. 360b. Further, under section 402(a)(4) of the Act, 21 U.S.C. 342(a)(4), a food is deemed to be adulterated if it has been held under insanitary conditions whereby it may have been rendered injurious to health.

Specifically, our investigation revealed that on or about July 6, 2009, you sold a culled dairy cow, identified with back tag (b)(4) for slaughter as food. On or about July 7, 2009, (b)(4) slaughtered this animal. United States Department of Agriculture, Food Safety and Inspection Service (USDA/FSIS) analysis of tissue samples collected from this animal identified the presence of 35.936 parts per million (ppm) of sulfamethazine residue in the muscle tissue and the presence of 32.294 ppm of sulfamethazine residue in the liver tissue. FDA has established a tolerance of 0.1 ppm for residues of sulfamethazine in the uncooked edible tissues of cattle as codified in Title 21, Code of Federal Regulations (C.F.R.), 556.670 (21 C.F.R. 556.670). The presence of this drug in edible tissue from this animal in this amount causes the food to be adulterated within the meaning of section 402(a)(2)(C)(ii) of the Act, 21 U.S.C. 342(a)(2)(C)(ii).

Our investigation also found that you hold animals under conditions that are so inadequate that medicated animals bearing potentially harmful drug residues are likely to enter the food supply. For example, you failed to maintain treatment records. Food from animals held under such conditions is adulterated within the meaning of section 402(a)(4) of the Act, 21 U.S.C. 342(a)(4).

We also found that you adulterated the new animal drug sulfamethazine. Specifically, our investigation revealed that you did not use sulfamethazine as directed by its approved labeling. Use of this drug in this manner is an extra-label use. See 21 C.F.R. 530.3(a). In addition, the extra-label use of sulfamethazine is prohibited in lactating dairy cows under 21 C.F.R. 530.41(a)(9).

The extra-label use of approved new animal or human drugs in animals is allowed under the Act only if the extra-label use complies with sections 512(a)(4) and (5) of the Act, 21 U.S.C. 360b(a)(4) and (5), and 21 C.F.R. Part 530, including that the use must be by or on the lawful order of a licensed veterinarian within the context of a valid veterinarian/client/patient relationship.

Our investigation found that you administered sulfamethazine to the culled dairy cow identified with back tag (b)(4) without following the dose and withdrawal period as stated in the approved labeling. Sulfamethazine is prohibited for extra-label use in lactating dairy cows by 21 C.F.R. 530.41(a)(9). Furthermore, your extra-label use of sulfamethazine resulted in an illegal drug residue, in violation of 21 C.F.R. 530.11(d). Because your use of this drug was not in conformance with its approved labeling and did not comply with 21 C.F.R. Part 530, you caused the drug to be unsafe under section 512(a) of the Act, 21 U.S.C. 360b(a), and adulterated within the meaning of section 501(a)(5) of the Act, 21 U.S.C. 351(a)(5).

The above is not intended to be an all-inclusive list of violations. As a producer of animals offered for use as food, you are responsible for ensuring that your overall operation and the food you distribute is in compliance with the law.

You should take prompt action to correct the violations described in this letter and to establish procedures to ensure that these violations do not recur. Failure to do so may result in regulatory action without further notice such as seizure and/or injunction.

You should notify this office in writing of the steps you have taken to bring your firm into compliance with the law within fifteen (15) working days of receiving this letter. Your response should include each step that has been taken or will be taken to correct the violations and prevent their recurrence. If corrective action cannot be completed within fifteen (15) working days of receiving this letter, state the reason for the delay and the time frame within which the corrections will be completed. Please include copies of any available documentation demonstrating that corrections have been made.

Your written response should be sent to Stephen J. Rabe, Compliance Officer, U.S. Food and Drug Administration, 6751 Steger Drive, Cincinnati, Ohio 45237. If you have any questions about this letter, please contact Mr. Rabe at 513-679-2700 ext. 163.

Sincerely, /S/

Karen Gale Sego Acting District Director Cincinnati District

Cc: Dr. William Thorn University of Kentucky Division of Regulatory Service 103 Regulatory Service Building Lexington, KY 40546-0275



http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm206359.htm


tss
 
The above animal was probably offerd for sale at a sale barn. After all, it did say she was a cull.

Well........... when sale barn animals are sold at auction, it's "buyer beware" unless stipulations are made before the sale.

When the cull cow buyer bought her, he should have kept her for a time period to cover vaccine withdrawals and should have been "Aware".

To me the buyer did not do his "due diligence", and should be punished instead of the dairy farmer.

All the farmer wanted to do was get rid of her so that he wouldn't have to feed her. Now they act like he's the criminal................ :roll:
 
Welcome to America in 2010! Ranchers and Farmers get blamed for anything that goes wrong but seldom get the credit for feeding the world. Look at how many people eat healthy, safe food EVERYDAY compared to the fraction of a fraction of 1% who get ill! :???: But nobody ever points that out! :mad: One cow with antibiotics residue is justification to slander and demonize an entire industry! :???:
 
leanin' H said:
Welcome to America in 2010! Ranchers and Farmers get blamed for anything that goes wrong but seldom get the credit for feeding the world. Look at how many people eat healthy, safe food EVERYDAY compared to the fraction of a fraction of 1% who get ill! :???: But nobody ever points that out! :mad: One cow with antibiotics residue is justification to slander and demonize an entire industry! :???:

Yep, that's old flounder!!!!!!!!!

Posting all his BSE "BS" like there's something we can do about it. :roll:

I hope I don't run across him one day. I'd be scared I might bust a knuckle on his head... :lol: :lol: :lol:
 
Mike said:
leanin' H said:
Welcome to America in 2010! Ranchers and Farmers get blamed for anything that goes wrong but seldom get the credit for feeding the world. Look at how many people eat healthy, safe food EVERYDAY compared to the fraction of a fraction of 1% who get ill! :???: But nobody ever points that out! :mad: One cow with antibiotics residue is justification to slander and demonize an entire industry! :???:

Yep, that's old flounder!!!!!!!!!

Posting all his BSE "BS" like there's something we can do about it. :roll:

I hope I don't run across him one day. I'd be scared I might bust a knuckle on his head... :lol: :lol: :lol:


stupid is as stupid does, and some times you just cannot fix stupid.

laugh all you want, your threats of violence on this board do not scare me.


kind regards,
terry
 
your threats of violence on this board do not scare me

Oh I wouldn't be violent about it. It would done with all the care I could muster to keep from busting that knuckle. :lol: :lol:

And you're right!!!!!!!!!!! I'll laugh all I want!!!!!!!!!!!!!!! :roll: :roll:
 
Mike said:
The above animal was probably offerd for sale at a sale barn. After all, it did say she was a cull.

Well........... when sale barn animals are sold at auction, it's "buyer beware" unless stipulations are made before the sale.

When the cull cow buyer bought her, he should have kept her for a time period to cover vaccine withdrawals and should have been "Aware".

To me the buyer did not do his "due diligence", and should be punished instead of the dairy farmer.

All the farmer wanted to do was get rid of her so that he wouldn't have to feed her. Now they act like he's the criminal................ :roll:


You don't sell a cull animal until the withdrawal times have been met. At least thats the way we do it here. I guess crooks down south that don't even put their names on their cattle when they sell would do it differently.
 
One of the problems with this is it costs us all in the prices we get for our cattle...In talking with some of the buyers they and the slaughterplant have to figure in the cost of what they lose with these animals that get rejected at slaughter because folks don't follow the instructions or break the rules..
And the dairy folks are the worst violators of pumping cows up...

A couple of the Lauras Lean (no antibiotics) buyers have told me that program is really tough on checking-- the reason sometimes its nice when you know the buyer- and they know you're not of the type that will try to slip something thru and its worth a few more cents...
 
Mike said:
The above animal was probably offerd for sale at a sale barn. After all, it did say she was a cull.

Well........... when sale barn animals are sold at auction, it's "buyer beware" unless stipulations are made before the sale.

When the cull cow buyer bought her, he should have kept her for a time period to cover vaccine withdrawals and should have been "Aware".

To me the buyer did not do his "due diligence", and should be punished instead of the dairy farmer.

All the farmer wanted to do was get rid of her so that he wouldn't have to feed her. Now they act like he's the criminal................ :roll:

It's the responsibility of the person that injected or fed those antibiotics to be sure withdrawal times have been observed before the animal is sent for slaughter. Since you have no control on what's done with the animal after it's sold it should not be sold until clean.
 
Big Muddy rancher said:
Mike said:
The above animal was probably offerd for sale at a sale barn. After all, it did say she was a cull.

Well........... when sale barn animals are sold at auction, it's "buyer beware" unless stipulations are made before the sale.

When the cull cow buyer bought her, he should have kept her for a time period to cover vaccine withdrawals and should have been "Aware".

To me the buyer did not do his "due diligence", and should be punished instead of the dairy farmer.

All the farmer wanted to do was get rid of her so that he wouldn't have to feed her. Now they act like he's the criminal................ :roll:

It's the responsibility of the person that injected or fed those antibiotics to be sure withdrawal times have been observed before the animal is sent for slaughter. Since you have no control on what's done with the animal after it's sold it should not be sold until clean.

Says you. If the buyer takes the animal to slaughter, all the while knowing about a withdrawal interval should be observed, then the onus is on him.

I have sold a many a cull dairy cow at the auction barn. But it just so happens I had them write on the ticket about the few who'd had anti-biotics.

Most of them went for nurse cows. The others hung around the buyers place until the withdrawal times were met, as far as I know.

It was either that, or chance it that the milk would be mistakenly put in the milk tank and maybe lose a couple of thousand gallons.

Now if a greedy azz cull cow buyer slipped her in at the killing plant, it was not my fault.
 
Mike said:
Big Muddy rancher said:
Mike said:
The above animal was probably offerd for sale at a sale barn. After all, it did say she was a cull.

Well........... when sale barn animals are sold at auction, it's "buyer beware" unless stipulations are made before the sale.

When the cull cow buyer bought her, he should have kept her for a time period to cover vaccine withdrawals and should have been "Aware".

To me the buyer did not do his "due diligence", and should be punished instead of the dairy farmer.

All the farmer wanted to do was get rid of her so that he wouldn't have to feed her. Now they act like he's the criminal................ :roll:

It's the responsibility of the person that injected or fed those antibiotics to be sure withdrawal times have been observed before the animal is sent for slaughter. Since you have no control on what's done with the animal after it's sold it should not be sold until clean.

Says you. If the buyer takes the animal to slaughter, all the while knowing about a withdrawal interval should be observed, then the onus is on him.

I have sold a many a cull dairy cow at the auction barn. But it just so happens I had them write on the ticket about the few who'd had anti-biotics.

Most of them went for nurse cows. The others hung around the buyers place until the withdrawal times were met, as far as I know.

It was either that, or chance it that the milk would be mistakenly put in the milk tank and maybe lose a couple of thousand gallons.

Now if a greedy azz cull cow buyer slipped her in at the killing plant, it was not my fault.

And thats the type not taking responsibility thinking that sticks us with more restrictions and new laws and rules- and may eventually lose producers the ability to get/administrate antibiotics and other drugs altogether.... :( :(
 
Oldtimer said:
Mike said:
Big Muddy rancher said:
It's the responsibility of the person that injected or fed those antibiotics to be sure withdrawal times have been observed before the animal is sent for slaughter. Since you have no control on what's done with the animal after it's sold it should not be sold until clean.

Says you. If the buyer takes the animal to slaughter, all the while knowing about a withdrawal interval should be observed, then the onus is on him.

I have sold a many a cull dairy cow at the auction barn. But it just so happens I had them write on the ticket about the few who'd had anti-biotics.

Most of them went for nurse cows. The others hung around the buyers place until the withdrawal times were met, as far as I know.

It was either that, or chance it that the milk would be mistakenly put in the milk tank and maybe lose a couple of thousand gallons.

Now if a greedy azz cull cow buyer slipped her in at the killing plant, it was not my fault.

And thats the type not taking responsibility thinking that sticks us with more restrictions and new laws and rules- and may eventually lose producers the ability to get/administrate antibiotics and other drugs altogether.... :( :(

:agree:
 
And thats the type not taking responsibility thinking that sticks us with more restrictions and new laws and rules- and may eventually lose producers the ability to get/administrate antibiotics and other drugs altogether....

Yep some of those buyers could get mighty unscrupulous.

Course I ain't been in the dairy business since 1974 and things have changed in 36 years.
 

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