BSE agent in spleen from an ARR/ARR orally exposed sheep

[flounder]

##################### Bovine Spongiform Encephalopathy #####################

Subject: BSE agent in spleen from an ARR/ARR orally exposed sheep
Date: March 12, 2006 at 6:30 am PST
Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep
Olivier Andréoletti1, Nathalie Morel2, Caroline Lacroux1, Virginie Rouillon1, Céline Barc3, Guillaume Tabouret1, Pierre Sarradin3, Patricia Berthon3, Philippe Bernardet3, Jacinthe Mathey1, Séverine Lugan1, Pierrette Costes1, Fabien Corbière1, Juan-Carlos Espinosa4, Juan Maria Torres4, Jacques Grassi2, François Schelcher1 and Frédéric Lantier3

1 UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France
2 CEA, Service de Pharmacologie et d'Immunologie, CEA/Saclay, 91191 Gif sur Yvette cedex, France
3 INRA, Pathologie Infectieuse et Immunologie, INRA Nouzilly, 37380 Nouzilly, France
4 CISA, Instituto National de Investigacion y Tecnologia Agraria y Alimentaria, 28130 Valdeolmos, Spain


Correspondence
Olivier Andréoletti
[email protected].

Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrPSc in the spleen.


http://vir.sgmjournals.org/cgi/content/abstract/87/4/1043



TSS

#################### https://lists.aegee.org/bse-l.html ####################

 

[Kathy]

flounder, perhaps you could post the entire study. I would like to know if the sheep actually developed any form of disease?

The current practice of slaughtering animals (sheep, cattle, mice, rats...) at an early age before the long term affects can be determined, has prevented study of PrPSc localization in older animals.

Dr. D. Matthews of VLA (UK guys that do the final BSE confirmation test), told Dr. M. Miller of Fort Collins, to kill the bloody animals at 3 months and get on with it.

No, we wouldn't want to look at the long term affects/results.

 

[flounder]

kathy wrote;


> flounder, perhaps you could post the entire study. I would like to know if the sheep actually

> developed any form of disease?


======================================

perhaps i could, but i will not, the study is long and you have cows to feed, remember


kathy wrote Fri Mar 10, 2006 on thread 91ST MEETING OF THE SEAC meeting in London on 24th February bottom of page 1 ;


> Terry this is all too lengthy, you need to cut to the chase with shorter bits. We have cattle to feed and
> care for.


:lol: :lol: :wink: .........TSS

 

[Kathy]

Terry your silence speaks louder than your words.

I'll find out if any of these sheep developed any illnesses myself, but, I suspect the answer already.

If they had got sick, you'd be the first to tell us.

 

[Econ101]

Kathy, do you need more that what the URL link has in it?

 

[Kathy]

Econo, no I see there is a correspondence address/contact.

The presence of PrPSc - does not confirm disease has or will take place in the future.

 

[bse-tester]

Kathy wrote:

The presence of PrPSc - does not confirm disease has or will take place in the future.

Hi Kathy, what do you base the above mentioned hypothesis on? It is an interesting statement and I would love to hear you explain it indepth if you would please.