holy mad elk disease, can't get it it up, dont take this

[flounder]

There are several supplements available for women with a weakened sex drive. Any combination of horny goat weed, dong quai, wild yam, ginseng, anise, turmeric and ginger will promote a healthier endocrine system function as well as increase energy in your body, vitality and natural desires.

For men, it is also about a similar group of herbal formulas-from a combination of deer antler velvet, morinda root, ginseng root, Senega root as well as horny goat weed. These herbs are useful when it comes to circulation, as in to the hormonal system and the testicles.




>>For men, it is also about a similar group of herbal formulas-from a combination of deer antler velvet,<<<


http://media.www.lewisflyer.com/media/storage/paper638/news/2009/03/18/Health/Stay-Vibrant-3672011.shtml



yep, antler velvet might help men 'get it up', but they might forget what they 'got it up' for, and then die from CJD with a boner they knew not what to do with. what a horrible way to go.


SERIOUSLY, THE CDC PUT OUT A WARNING ON THIS JUST THIS PAST WEEK, FAST TRACKED I.E. MAY 2009. sadly, myself and others have been warning about this for a decade or more.



FOR YOUR INFORMATION, MAY 2009, CDC IS WARNING FOLKS OF PRION DISEASE FROM CWD IN ANTLER VELVET NUTRITIONAL SUPPLEMENTS !


I find this study most important.

some of us have been saying this for years, myself, i made a submission to the BSE Inquiry in England in 1998. At least they listened.

But i thought some of you would be interested in this.

I don't care really what anybody eats, and or, if you want to pour a gallon of urine on yourself, if it makes you feel good, to go for a hunt. whatever turns you on.

BUT, when you have the CDC finally come out with a warning like this after so many years of floundering, better late than never i suppose, but how many were exposed needlessly???

----- Original Message ----- From: "TERRY SINGELTARY" <[email protected]> To: <[email protected]> Sent: Thursday, March 19, 2009 8:47 PM Subject: [CJD-L] Chronic Wasting Disease Prions in Elk Antler Velvet (Nutritional Supplements and CJD)

10.3201/eid1505.081458 Suggested citation for this article: Angers RC, Seward TS, Napier D, Green M, Hoover E, Spraker T, et al. Chronic wasting disease prions in elk antler velvet. Emerg Infect Dis. 2009 May; [Epub ahead of print]

Chronic Wasting Disease Prions in Elk Antler Velvet

Rachel C. Angers,1 Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O'Rourke, Aru Balachandran, and Glenn C. Telling Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O'Rourke); and Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran) 1Current affiliation: MRC Laboratory of Molecular Biology, Cambridge, UK.

Chronic wasting disease (CWD) is a contagious, fatal prion disease of deer and elk that continues to emerge in new locations. To explore the means by which prions are transmitted with high efficiency among cervids, we examined prion infectivity in the apical skin layer covering the growing antler (antler velvet) by using CWD-susceptible transgenic mice and protein misfolding cyclic amplification. Our finding of prions in antler velvet of CWD-affected elk suggests that this tissue may play a role in disease transmission among cervids. Humans who consume antler velvet as a nutritional supplement are at risk for exposure to prions. The fact that CWD prion incubation times in transgenic mice expressing elk prion protein are consistently more rapid raises the possibility that residue 226, the sole primary structural difference between deer and elk prion protein, may be a major determinant of CWD pathogenesis.

snip...

Discussion

The transmission of CWD prions in antler velvet from 2 naturally affected elk to mice in 2 Tg models demonstrates that this tissue contains low, but detectable, amounts of CWD prions. In addition, serial PMCA amplified otherwise undetectable levels of PrPSc in antler velvet. We characterized CWD prion infectivity by end-point titration. The .6 log i.c.ID50/g CWD prion titer estimated by this method contrasts with .9 log i.c.ID50/g titers of mouse-adapted scrapie prions in rodent brains (9) and .7.7.7 log i.c.ID50/g titers of BSE prions estimated by bioassay in transgenic mice (10,11). The linear relationship between dose and incubation time (12) provides an opportunity to estimate the level of prions in materials containing an unknown amount of infectivity. The attack rates of <100% after inoculation with antler velvet preparations from elk 01-0306 and 03-0306 and the failure to transmit disease from the remaining antler velvet samples suggest that CWD prion titers are close to, or at, the end point of the Tg(CerPrP)1536+/. bioassay. Although we are aware of the limitations of comparing levels of prions in tissues from different CWD-affected cervids, we estimate the end point of the CWD prion titration using D92 to be <3.5 log i.c.ID50 units. Other factors could also influence levels of infectivity in the 4 tested samples, e.g., the portion of the antler processed and the age of the antler when harvested. Histologic evaluation indicated that the velvet samples used in these transmission studies came from elk antlers in the early stages of seasonal growth (data not shown). Whether CWD prion titers in antler velvet vary according to the state of antler growth remains to be determined. Whether prion infectivity is derived from nervous system tissue, blood (13), or another component of velvet, is also unclear. Implications for Horizontal CWD Transmission and Human Exposure Our studies indicate that antler velvet represents a previously unrecognized source of CWD prions in the environment. Whereas oral transmission of rodent-adapted scrapie prions is known to be .5 orders of magnitude less efficient than transmission by intracerebral inoculation (14,15), the relative efficiency of oral CWD prion transmission is unknown. Multiple exposures

Page 7 of 17

to low levels of CWD prions in the environment (16,17), as well as increased infectivity when prions are bound to soil minerals (18), are factors that may influence transmission. The appearance of variant Creutzfeldt-Jakob disease in humans exposed to bovine spongiform encephalopathy (BSE) (19,20) and the demonstration of CWD prions in muscle (3) placed the human species barrier to CWD prions at the forefront of public health concerns. Our studies indicate that antler velvet represents an additional source for human exposure to CWD prions. Widely used in traditional Asian medicine to treat a variety of ailments including impotence, arthritis and high blood pressure, antler velvet can be readily purchased in caplet form and its usage has increased worldwide. Fortunately, to date there is no epidemiologic evidence for increased rates of CJD in the CWD-endemic region (Colorado, USA) (21,22). Also reassuring is the inefficient in vitro conversion of human PrP to protease-resistant PrP by CWD (23). Two studies have shown that CWD prions failed to induce disease in Tg mice expressing human PrP (24,25). However, the failure of BSE to be transmitted to Tg mice expressing human prion protein (HuPrP) was cited as early evidence for a BSE transmission barrier in humans (26); subsequent studies demonstrated a strong effect of the codon 129 polymorphism on transmissibility of BSE prions (27). To date, only mice expressing HuPrP with methionine at 129 have been challenged with CWD. In support of the argument that humans might be susceptible to CWD, intracerebral inoculation of squirrel monkeys produced disease after >30 months (28). Prion strain properties are also critical when considering the potential for interspecies transmission. The existence of multiple CWD strains has been suggested by several studies (4,25,29,30), but strain isolation and host range characterization have not been reported. Finally, it is worth considering that if CWD were to cross the species barrier into humans, this transmission source might not be recognized if the disease profile overlapped with one of the forms of sporadic CJD reported in North America.

Possible Role for Residue 226 in CWD Pathogenesis

Previous studies that demonstrated more rapid CWD prion incubation times in Tg mice expressing elk PrP (24,29) than in Tg(CerPrP)1536+/. mice (4) raised the possibility that the single amino acid difference at residue 226 between elk and deer PrP (5) may influence CWD pathogenesis (29). However, when the transmission characteristics of CWD isolates were directly compared in Tg mice expressing differing levels of deer or elk PrP, Tamguney et al.

Page 8 of 17

concluded that CWD incubation times were related solely to the level of PrP transgene expression (25). We compared CWD transmission in Tg(CerPrP-E226)5037+/. and Tg(CerPrP)1536+/. mice, which express PrP at levels .5-fold higher than PrP in wild type mouse brain (Figure 1A), and found that CWD transmission was consistently and substantially more rapid in Tg(CerPrP-E226)5037+/. mice. Our results appear compatible with more efficient CWD prion propagation by elk cellular prion protein (CerPrPC) containing E at residue 226 than by deer CerPrPC containing Q at this position. Consistent with this interpretation, despite 5-fold lower levels of transgene expression in Tg(CerPrP-E226)5029+/. than in Tg(CerPrP)1536+/. mice, mean incubation times of the D92 isolate were equivalent in these 2 lines (Table). Nonetheless, undetected differences in CerPrPC expression, for example in particular cell types, might result in more rapid disease and/or altered pathologic changes. The generation of transgenic mice expressing elk and deer coding sequences using gene replacement strategies would seem to be an excellent approach for resolving this issue. The different responses to CWD in Tg mice also appear to recapitulate aspects of CWD pathogenesis in the natural hosts. Previous limited comparative transmission studies indicated that CWD developed .25% more rapidly in orally challenged elk than deer (31). Although plaques were not detected in brains of CWD-affected elk, florid plaques have been observed in the brains of diseased deer (32,33). Similar differences in pathologic changes were observed in Tg(CerPrP-E226)5037+/. and Tg(CerPrP)1536+/. mice (Figure 4). Structural analyses suggest that residue 226 is located within a region of PrPC proposed to interact with a factor (34), possibly equivalent to the postulated protein X (35). Although mutation of the equivalent residue from Q to lysine (K) in epitope-tagged mouse PrP had no effect on PrPSc formation in transfected chronically infected ScN2A cells, the effects of the Q-to-E substitution were not assessed (36).

Acknowledgments We thank Dongyue Zhuang for excellent technical assistance. This work was supported by grants 2RO1NS040334-04 from the National Institute

http://www.cdc.gov/eid/content/15/5/pdfs/08-1458.pdf

snip...

1998 MY SUBMISSION TO THE BSE INQUIRY ENGLAND

Sender: "Patricia Cantos" <patricia.cantos at bse.org.uk> To: "Terry S Singeltary Sr. (E-mail)" <flounder at wt.net> Subject: Your submission to the Inquiry Date: Fri, 3 Jul 1998 10:10:05 +0100

3 July 1998 Mr Terry S Singeltary Sr. E-Mail: Flounder at wt.net Ref: E2979

Dear Mr Singeltary,

Thank you for your E-mail message of the 30th of June 1998 providing the Inquiry with your further comments. Thank you for offering to provide the Inquiry with any test results on the nutritional supplements your mother was taking before she died.

As requested I am sending you our general Information Pack and a copy of the Chairman's letter. Please contact me if your system cannot read the attachments.

Regarding your question, the Inquiry is looking into many aspects of the scientific evidence on BSE and nvCJD. I would refer you to the transcripts of evidence we have already heard which are found on our internet site at http://www.bse.org.uk. Could you please provide the Inquiry with a copy of the press article you refer to in your e-mail? If not an approximate date for the article so that we can locate it? In the meantime, thank you for you comments. Please do not hesitate to contact me on 0171 261 8332 should you have any queries.

Yours sincerely Patricia Cantos Families Team Leader Attachments TSS

==============

-------- Original Message --------

Subject: re: METABOLIFE AND TSEs GAO-03-494 ''URGENT DATA'' Date: Thu, 01 May 2003 16:04:35 -0400 From: "Marcia G Crosse" <CrosseM at gao.gov> To: <flounder at wt.net> CC: "Charles W Davenport" <DavenportC at gao.gov>, "Carolyn Feis Korman" <FeisKormanC at gao.gov>, "Martin Gahart" <GahartM at gao.gov>

Mr. Singletary,

We were informed by representatives of Metabolife, Inc. that Metabolife 356 was reformulated to remove bovine complex as an ingredient in the product, approximately September 2001. We did not independently verify the contents of the product.

Sincerely, Marcia Crosse Acting Director Health CarePublic Health and Science Issues U.S. General Accounting Office 441 G Street, N.W. Washington, D.C. 20548

===================

-------- Original Message -------- Subject: Re: METABOLIFE AND TSEs GAO-03-494 ''URGENT DATA'' Date: Thu, 01 May 2003 15:48:52 -0500 From: "Terry S. Singeltary Sr." <flounder at wt.net> To: Marcia G Crosse <CrosseM at gao.gov> CC: Charles W Davenport <DavenportC at gao.gov>, Carolyn Feis Korman <FeisKormanC at gao.gov>, Martin Gahart <GahartM at gao.gov> References: <seb14599.014 at GAOGWIA1.GAO.GOV>

THANK YOU!

MIRACLES DO HAPPEN! ;-)

now all we need to do is;

snip......

one small step for man, one giant leap for mankind ;-)

however;

''We did not independently verify the contents of the product''

???

TSS

####### http://mailhost.rz.uni-karlsruhe.de/warc/bse-l.html ########

see history of mad cow in a pill ;

Thursday, March 19, 2009

Chronic Wasting Disease Prions in Elk Antler Velvet (Nutritional Supplements and CJD)

http://chronic-wasting-disease.blogspot.com/2009/03/chronic-wasting-disease-prions-in-elk.html

Wednesday, March 18, 2009

Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay

http://chronic-wasting-disease.blogspot.com/2009/03/detection-of-cwd-prions-in-urine-and.html

RECALLS AND FIELD CORRECTIONS: FOODS CLASS II

___________________________________

PRODUCT

a) Elk Meat, Elk Tenderloin, Frozen in plastic vacuum packaging. Each package is approximately 2 lbs., and each case is approximately 16 lbs.; Item number 755125, Recall # F-129-9;

b) Elk Meat, Elk Trim, Frozen; Item number 755155, Recall # F-130-9;

c) Elk Meat, French Rack, Chilled. Item number 755132, Recall # F-131-9;

d) Elk Meat, Nude Denver Leg. Item number 755122, Recall # F-132-9;

e) Elk Meat, New York Strip Steak, Chilled. Item number 755128, Recall # F-133-9;

f) Elk Meat, Flank Steak Frozen. Item number 755131, Recall # F-134-9;

CODE

Elk Meats with production dates of December 29, 30, and 31

RECALLING FIRM/MANUFACTURER

Recalling Firm: Sierra Meats, Reno, NV, by telephone on January 29, 2009 and press release on February 9, 2009.

Manufacturer: Noah's Ark Holding, LLC, Dawson, MN. Firm initiated recall is ongoing.

REASON

Elk products contain meat derived from an elk confirmed to have Chronic Wasting Disease (CWD).

VOLUME OF PRODUCT IN COMMERCE

Unknown

DISTRIBUTION

NV, CA, TX, CO, NY, UT, FL, OK

___________________________________

http://www.fda.gov/bbs/topics/ENFORCE/2009/ENF01099.html

Monday, February 09, 2009

Exotic Meats USA Announces Urgent Statewide Recall of Elk Tenderloin Because It May Contain Meat Derived From An Elk Confirmed To Have CWD

snip...

Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain

Date: August 25, 2007 at 12:42 pm PST

our results raise the possibility that CJD cases classified as VV1 may include cases caused by iatrogenic transmission of sCJD-MM1 prions or food-borne infection by type 1 prions from animals, e.g., chronic wasting disease prions in cervid. In fact, two CJD-VV1 patients who hunted deer or consumed venison have been reported (40, 41). The results of the present study emphasize the need for traceback studies and careful re-examination of the biochemical properties of sCJD-VV1 prions.

http://www.jbc.org/

snip...

Clearly, it is premature to draw firm conclusions about CWD passing naturally into humans, cattle and sheep, but the present results suggest that CWD transmissions to humans would be as limited by PrP incompatibility as transmissions of BSE or sheep scrapie to humans. Although there is no evidence that sheep scrapie has affected humans, it is likely that BSE has caused variant CJD in 74 people (definite and probable variant CJD cases to date according to the UK CJD Surveillance Unit). Given the presumably large number of people exposed to BSE infectivity, the susceptibility of humans may still be very low compared with cattle, which would be consistent with the relatively inefficient conversion of human PrP-sen by PrPBSE. Nonetheless, since humans have apparently been infected by BSE, it would seem prudent to take reasonable measures to limit exposure of humans (as well as sheep and cattle) to CWD infectivity as has been recommended for other animal TSEs.

snip...

http://www.emboj.org/current.shtml

snip

http://www.cdc.gov/ncidod/EID/vol10no6/03-1082.htm

From: TSS (216-119-163-189.ipset45.wt.net) Subject: CWD aka MAD DEER/ELK TO HUMANS ??? Date: September 30, 2002 at 7:06 am PST

From: "Belay, Ermias" To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias" Sent: Monday, September 30, 2002 9:22 AM Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

Dear Sir/Madam, In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.

That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.

Ermias Belay, M.D. Centers for Disease Control and Prevention

-----Original Message----- From: Sent: Sunday, September 29, 2002 10:15 AM To: [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask] Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS

snip...

full text ;

http://chronic-wasting-disease.blogspot.com/2009/02/exotic-meats-usa-announces-urgent.html

Wednesday, March 18, 2009 Noah's Ark Holding, LLC, Dawson, MN RECALL Elk products contain meat derived from an elk confirmed to have CWD NV, CA, TX, CO, NY, UT, FL, OK RECALLS AND FIELD CORRECTIONS: FOODS CLASS II

http://chronic-wasting-disease.blogspot.com/2009/03/noahs-ark-holding-llc-dawson-mn-recall.html



============================================================



Saturday, January 24, 2009

Bovine Spongiform Encephalopathy h-BSE ATYPICAL USA 2008 Annual Report Research Project: Study of Atypical Bse

Location: Virus and Prion Diseases of Livestock

2008 Annual Report

http://bse-atypical.blogspot.com/2009/01/bovine-spongiform-encephalopathy-h-bse.html

Thursday, December 04, 2008 2:37 PM

"we have found that H-BSE can infect humans."

personal communication with Professor Kong. ...TSS

see full text ;

http://bse-atypical.blogspot.com/2009/02/atypical-bse-north-america-update.html



Wednesday, February 04, 2009

Creutzfeldt-Jacob disease presenting as severe depression: a case report


http://creutzfeldt-jakob-disease.blogspot.com/2009/02/creutzfeldt-jacob-disease-presenting-as.html


A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: analysis of potential risk factors with regard to an increased CJD incidence in the years 2001-2004


http://creutzfeldt-jakob-disease.blogspot.com/2009/02/case-control-study-of-sporadic.html



Sunday, August 10, 2008 A New Prionopathy OR more of the same old BSe and sporadic CJD


http://creutzfeldt-jakob-disease.blogspot.com/2008/08/new-prionopathy-or-more-of-same-old-bse.html



Sunday, March 16, 2008 MAD COW DISEASE terminology UK c-BSE (typical), atypical BSE H or L, and or Italian L-BASE


http://bse-atypical.blogspot.com/2008/03/mad-cow-disease-terminology-uk-c-bse.html


HUMAN and ANIMAL TSE Classifications i.e. mad cow disease and the UKBSEnvCJD only theory JUNE 2008

snip...

Tissue infectivity and strain typing of the many variants Manuscript of the human and animal TSEs are paramount in all variants of all TSE. There must be a proper classification that will differentiate between all these human TSE in order to do this. With the CDI and other more sensitive testing coming about, I only hope that my proposal will some day be taken seriously. ...

snip...

http://cjdmadcowbaseoct2007.blogspot.com/2008/06/human-and-animal-tse-classifications-ie.html


Elsevier Editorial System(tm) for The Lancet Infectious Diseases Manuscript Draft Manuscript Number: Title: HUMAN and ANIMAL TSE Classifications i.e. mad cow disease and the UKBSEnvCJD only theory Article Type: Personal View Corresponding Author: Mr. Terry S. Singeltary, Corresponding Author's Institution: na First Author: Terry S Singeltary, none Order of Authors: Terry S Singeltary, none; Terry S. Singeltary

Abstract:

TSEs have been rampant in the USA for decades in many species, and they all have been rendered and fed back to animals for human/animal consumption. I propose that the current diagnostic criteria for human TSEs only enhances and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD only theory in 2007. snip...

see full text 31 pages ;


http://www.regulations.gov/fdmspublic/ContentViewer?objectId=090000648027c28e&disposition=attachment&contentType=pdf


CJD QUESTIONNAIRE USA CWRU AND CJD FOUNDATION

http://cjdquestionnaire.blogspot.com/



http://www.wapiti.net/discussion/showPost.cfm?post=60219




TSS

 

[Tex]

Terry, do you know where the elk were from? Were they "farm" raised and if so, what state or area?

 

[flounder]

Terry, do you know where the elk were from? Were they "farm" raised and if so, what state or area?

hey there tex,

IN the study at the beginning of my post about the antler velvet, those cwd infected elk WERE NATURALLY AFFECTED CWD FROM CANADA, AND SOME WERE FROM COLORADO DIV WILDLIFE RESEARCH CENTER, AND SOME FROM CWD-AFFECTED ELK AT THE Wyoming Game and Fish Department's Sybille Wildlife Research Unit. SEE ;

Antler velvet and matching brain samples were obtained from 4 elk from Canada that were naturally affected with CWD. Elk 01-0306 had severe CWD-specific neuropathologic changes in the obex and neurologic signs indicative of CWD; elk 02-0306 had moderate neuropathologic changes in the obex and was clinically normal. Although information about the clinical status of elk 03-0306 and 04-0306 was not available, these elk had mild and severe neuropathologic changes, respectively, in the obex.

Brain samples were also obtained from CWD-affected mule deer D10 and D92 at the Colorado Division of Wildlife, Wildlife Research Center, and from CWD-affected elk 7378 and 99W12389 at the Wyoming Game and Fish Department's Sybille Wildlife Research Unit. Homogenates of brain and antler velvet (10% wt/vol) were prepared in sterile phosphate-buffered saline (PBS) lacking Ca2+ and Mg2+ ions.

http://www.cdc.gov/eid/content/15/5/pdfs/08-1458.pdf

TEX, IF you were talking about the recalls posted below that, of the cwd infected meat that went out into commerce, the origin of that was ;

The infected elk came from __Elk Farm LLC in Pine Island, MN__ and was among animals slaughtered and processed at USDA facility Noah's Ark Processors LLC.

http://www.fda.gov/oc/po/firmrecalls/exoticmeats02_09.html

RECALLING FIRM/MANUFACTURER

Recalling Firm: Sierra Meats, Reno, NV, by telephone on January 29, 2009 and press release on February 9, 2009.

Manufacturer: Noah's Ark Holding, LLC, Dawson, MN. Firm initiated recall is ongoing.

REASON

Elk products contain meat derived from an elk confirmed to have Chronic Wasting Disease (CWD).

VOLUME OF PRODUCT IN COMMERCE

Unknown

DISTRIBUTION

NV, CA, TX, CO, NY, UT, FL, OK

RECALLING FIRM/MANUFACTURER

Recalling Firm: Sierra Meats, Reno, NV, by telephone on January 29, 2009 and press release on February 9, 2009.

Manufacturer: Noah's Ark Holding, LLC, Dawson, MN. Firm initiated recall is ongoing.

REASON

Elk products contain meat derived from an elk confirmed to have Chronic Wasting Disease (CWD).

VOLUME OF PRODUCT IN COMMERCE

Unknown

DISTRIBUTION

NV, CA, TX, CO, NY, UT, FL, OK

http://www.fda.gov/bbs/topics/ENFORCE/2009/ENF01099.html

http://chronic-wasting-disease.blogspot.com/2009/03/noahs-ark-holding-llc-dawson-mn-recall.html

TSS

 

[Tex]

Thanks y'all. Reader, we all know the regulatory agencies in the USA have been out to lunch for the last 10 years. I just wish the people who put them on vacation could be held accountable instead of innocent people they failed to protect.

By the way, I thought the antler industry came mostly from red deer (one of my neighbors has some) instead of elk.

I don't buy the meat or antler products but I like elk and elk hunting. This is a real bummer when it comes to wildlife and all the people that are potentially affected from sportsmen to all who buy these products.

 

[bse-tester]

Here in Alberta the lunacy is alive and well among those who raise elk on farms. Their self-appointed expert on prion disease, Glenda Elkow (Mmmmm) has come out swinging at the Edmonton Journal saying that the newspaper misrepresented the facts surrounding CWD and the potential threat to human health. She bases this on the argument that Tg mice were used in the study and then implies that this means the study is flawed.

I have read some self-serving drivel in my life and this borders on being almost a reprint of what was offered up by the UK Commission put together to study the dangers and potential harm that could result from the UK BSE Crisis. Of course, the UK Commission was made up of self-interest groups such as the UK Dairy Prducers, The UK Cattle & Beef Export Group, The UK Milk Producers Association and so on and so on.

Glenda Elkow, the Chairwoman of the Alberta Elk Commission, stated that she was concerned that there was no mention of a study that proved that:
"....the results of previous research that proved that the CWD prion is not present in elk antler."

Obviously, she is not aware of current prion research Terry.

She is painfully ignorant of the fact that the CWD prp is virtually identical in isoform to that which causes BSE, vCJD and also CJD. The entire science of TSE study utilizes Tg mice and other inoculant subjects to prove transmission studies and yet this woman seems to think that because a mouse received this inoculant, it voids the study. She mentions that the mouse was genetically altered to make the study affective.

She even says clearly that the USA over-reacted when they closed the borders and that the Edmonton Journal published an article April 4, 2009 which read:

"Your misleading sub-heading overemphasized the risk to people based on the control mechanisms in place and the abundant research that fails to link CWD to humans."

I guess the next time I get hold of a sample of CWD Whitetail Deer meat for testing, I should invite her over for a BBQ. I might even be able to acquire some Elk Tender Loin that is also CWD positive, but that BBQ will be in Denver. It would be interesting to see if she would be willing to chow down on it???

The point I am making here is simply this: If you wish to protect your bottom line Glenda and that of your membership, do not do it at the expense of the consumer by trying to argue with the science. TG mice are not the problem here - hiding the truth under a blanket called "The Bottom Line" is the problem.

Terry, do you have a firm date on that publish date from CDC? I heard it was going to be around mid-month?

Ron.

Now that folks, it too weird to consider! I must rush home and watch the movie "The Fly."

 

[flounder]

Here in Alberta the lunacy is alive and well among those who raise elk on farms. Their self-appointed expert on prion disease, Glenda Elkow (Mmmmm) has come out swinging at the Edmonton Journal saying that the newspaper misrepresented the facts surrounding CWD and the potential threat to human health. She bases this on the argument that Tg mice were used in the study and then implies that this means the study is flawed.

I have read some self-serving drivel in my life and this borders on being almost a reprint of what was offered up by the UK Commission put together to study the dangers and potential harm that could result from the UK BSE Crisis. Of course, the UK Commission was made up of self-interest groups such as the UK Dairy Prducers, The UK Cattle & Beef Export Group, The UK Milk Producers Association and so on and so on.

Glenda Elkow, the Chairwoman of the Alberta Elk Commission, stated that she was concerned that there was no mention of a study that proved that:
"....the results of previous research that proved that the CWD prion is not present in elk antler."

Obviously, she is not aware of current prion research Terry.

She is painfully ignorant of the fact that the CWD prp is virtually identical in isoform to that which causes BSE, vCJD and also CJD. The entire science of TSE study utilizes Tg mice and other inoculant subjects to prove transmission studies and yet this woman seems to think that because a mouse received this inoculant, it voids the study. She mentions that the mouse was genetically altered to make the study affective.

She even says clearly that the USA over-reacted when they closed the borders and that the Edmonton Journal published an article April 4, 2009 which read:

"Your misleading sub-heading overemphasized the risk to people based on the control mechanisms in place and the abundant research that fails to link CWD to humans."

I guess the next time I get hold of a sample of CWD Whitetail Deer meat for testing, I should invite her over for a BBQ. I might even be able to acquire some Elk Tender Loin that is also CWD positive, but that BBQ will be in Denver. It would be interesting to see if she would be willing to chow down on it???

The point I am making here is simply this: If you wish to protect your bottom line Glenda and that of your membership, do not do it at the expense of the consumer by trying to argue with the science. TG mice are not the problem here - hiding the truth under a blanket called "The Bottom Line" is the problem.

Terry, do you have a firm date on that publish date from CDC? I heard it was going to be around mid-month?

Ron.

Now that folks, it too weird to consider! I must rush home and watch the movie "The Fly."

hell ron, i posted it weeks ago. it was a fast track from the cdc site dated May 2009. also, read what Belay et al told me in reference to their cwd to humans study. also, do you really think they would be recalling all that cwd positive elk meat from all those states if there was not a substantial risk factor of cwd to humans. and in regards to those supplements, that's all in the hell we were feeding the cattle, same thing. it's of no surprise to me. ...terry



http://www.cdc.gov/eid/content/15/5/pdfs/08-1458.pdf



10.3201/eid1505.081458 Suggested citation for this article: Angers RC, Seward TS, Napier D, Green M, Hoover E, Spraker T, et al. Chronic wasting disease prions in elk antler velvet. Emerg Infect Dis. 2009 May; [Epub ahead of print]

Chronic Wasting Disease Prions in Elk Antler Velvet

Rachel C. Angers,1 Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O'Rourke, Aru Balachandran, and Glenn C. Telling Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O'Rourke); and Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran) 1Current affiliation: MRC Laboratory of Molecular Biology, Cambridge, UK.

Chronic wasting disease (CWD) is a contagious, fatal prion disease of deer and elk that continues to emerge in new locations. To explore the means by which prions are transmitted with high efficiency among cervids, we examined prion infectivity in the apical skin layer covering the growing antler (antler velvet) by using CWD-susceptible transgenic mice and protein misfolding cyclic amplification. Our finding of prions in antler velvet of CWD-affected elk suggests that this tissue may play a role in disease transmission among cervids. Humans who consume antler velvet as a nutritional supplement are at risk for exposure to prions. The fact that CWD prion incubation times in transgenic mice expressing elk prion protein are consistently more rapid raises the possibility that residue 226, the sole primary structural difference between deer and elk prion protein, may be a major determinant of CWD pathogenesis.

snip...

Discussion

The transmission of CWD prions in antler velvet from 2 naturally affected elk to mice in 2 Tg models demonstrates that this tissue contains low, but detectable, amounts of CWD prions. In addition, serial PMCA amplified otherwise undetectable levels of PrPSc in antler velvet. We characterized CWD prion infectivity by end-point titration. The .6 log i.c.ID50/g CWD prion titer estimated by this method contrasts with .9 log i.c.ID50/g titers of mouse-adapted scrapie prions in rodent brains (9) and .7.7.7 log i.c.ID50/g titers of BSE prions estimated by bioassay in transgenic mice (10,11). The linear relationship between dose and incubation time (12) provides an opportunity to estimate the level of prions in materials containing an unknown amount of infectivity. The attack rates of <100% after inoculation with antler velvet preparations from elk 01-0306 and 03-0306 and the failure to transmit disease from the remaining antler velvet samples suggest that CWD prion titers are close to, or at, the end point of the Tg(CerPrP)1536+/. bioassay. Although we are aware of the limitations of comparing levels of prions in tissues from different CWD-affected cervids, we estimate the end point of the CWD prion titration using D92 to be <3.5 log i.c.ID50 units. Other factors could also influence levels of infectivity in the 4 tested samples, e.g., the portion of the antler processed and the age of the antler when harvested. Histologic evaluation indicated that the velvet samples used in these transmission studies came from elk antlers in the early stages of seasonal growth (data not shown). Whether CWD prion titers in antler velvet vary according to the state of antler growth remains to be determined. Whether prion infectivity is derived from nervous system tissue, blood (13), or another component of velvet, is also unclear. Implications for Horizontal CWD Transmission and Human Exposure Our studies indicate that antler velvet represents a previously unrecognized source of CWD prions in the environment. Whereas oral transmission of rodent-adapted scrapie prions is known to be .5 orders of magnitude less efficient than transmission by intracerebral inoculation (14,15), the relative efficiency of oral CWD prion transmission is unknown. Multiple exposures

Page 7 of 17

to low levels of CWD prions in the environment (16,17), as well as increased infectivity when prions are bound to soil minerals (18), are factors that may influence transmission. The appearance of variant Creutzfeldt-Jakob disease in humans exposed to bovine spongiform encephalopathy (BSE) (19,20) and the demonstration of CWD prions in muscle (3) placed the human species barrier to CWD prions at the forefront of public health concerns. Our studies indicate that antler velvet represents an additional source for human exposure to CWD prions. Widely used in traditional Asian medicine to treat a variety of ailments including impotence, arthritis and high blood pressure, antler velvet can be readily purchased in caplet form and its usage has increased worldwide. Fortunately, to date there is no epidemiologic evidence for increased rates of CJD in the CWD-endemic region (Colorado, USA) (21,22). Also reassuring is the inefficient in vitro conversion of human PrP to protease-resistant PrP by CWD (23). Two studies have shown that CWD prions failed to induce disease in Tg mice expressing human PrP (24,25). However, the failure of BSE to be transmitted to Tg mice expressing human prion protein (HuPrP) was cited as early evidence for a BSE transmission barrier in humans (26); subsequent studies demonstrated a strong effect of the codon 129 polymorphism on transmissibility of BSE prions (27). To date, only mice expressing HuPrP with methionine at 129 have been challenged with CWD. In support of the argument that humans might be susceptible to CWD, intracerebral inoculation of squirrel monkeys produced disease after >30 months (28). Prion strain properties are also critical when considering the potential for interspecies transmission. The existence of multiple CWD strains has been suggested by several studies (4,25,29,30), but strain isolation and host range characterization have not been reported. Finally, it is worth considering that if CWD were to cross the species barrier into humans, this transmission source might not be recognized if the disease profile overlapped with one of the forms of sporadic CJD reported in North America.

Possible Role for Residue 226 in CWD Pathogenesis

Previous studies that demonstrated more rapid CWD prion incubation times in Tg mice expressing elk PrP (24,29) than in Tg(CerPrP)1536+/. mice (4) raised the possibility that the single amino acid difference at residue 226 between elk and deer PrP (5) may influence CWD pathogenesis (29). However, when the transmission characteristics of CWD isolates were directly compared in Tg mice expressing differing levels of deer or elk PrP, Tamguney et al.

Page 8 of 17

concluded that CWD incubation times were related solely to the level of PrP transgene expression (25). We compared CWD transmission in Tg(CerPrP-E226)5037+/. and Tg(CerPrP)1536+/. mice, which express PrP at levels .5-fold higher than PrP in wild type mouse brain (Figure 1A), and found that CWD transmission was consistently and substantially more rapid in Tg(CerPrP-E226)5037+/. mice. Our results appear compatible with more efficient CWD prion propagation by elk cellular prion protein (CerPrPC) containing E at residue 226 than by deer CerPrPC containing Q at this position. Consistent with this interpretation, despite 5-fold lower levels of transgene expression in Tg(CerPrP-E226)5029+/. than in Tg(CerPrP)1536+/. mice, mean incubation times of the D92 isolate were equivalent in these 2 lines (Table). Nonetheless, undetected differences in CerPrPC expression, for example in particular cell types, might result in more rapid disease and/or altered pathologic changes. The generation of transgenic mice expressing elk and deer coding sequences using gene replacement strategies would seem to be an excellent approach for resolving this issue. The different responses to CWD in Tg mice also appear to recapitulate aspects of CWD pathogenesis in the natural hosts. Previous limited comparative transmission studies indicated that CWD developed .25% more rapidly in orally challenged elk than deer (31). Although plaques were not detected in brains of CWD-affected elk, florid plaques have been observed in the brains of diseased deer (32,33). Similar differences in pathologic changes were observed in Tg(CerPrP-E226)5037+/. and Tg(CerPrP)1536+/. mice (Figure 4). Structural analyses suggest that residue 226 is located within a region of PrPC proposed to interact with a factor (34), possibly equivalent to the postulated protein X (35). Although mutation of the equivalent residue from Q to lysine (K) in epitope-tagged mouse PrP had no effect on PrPSc formation in transfected chronically infected ScN2A cells, the effects of the Q-to-E substitution were not assessed (36).

Acknowledgments We thank Dongyue Zhuang for excellent technical assistance. This work was supported by grants 2RO1NS040334-04 from the National Institute

http://www.cdc.gov/eid/content/15/5/pdfs/08-1458.pdf



FDA ET AL ARE NOT RECALLING ALL THIS CWD POSITIVE ELK MEAT, FOR THE WELL BEING OF THE ELK !!!




RECALLS AND FIELD CORRECTIONS: FOODS CLASS II

___________________________________




PRODUCT




a) Elk Meat, Elk Tenderloin, Frozen in plastic vacuum packaging. Each
package is approximately 2 lbs., and each case is approximately 16 lbs.;
Item number 755125, Recall # F-129-9;



b) Elk Meat, Elk Trim, Frozen; Item number 755155, Recall # F-130-9;



c) Elk Meat, French Rack, Chilled. Item number 755132, Recall # F-131-9;



d) Elk Meat, Nude Denver Leg. Item number 755122, Recall # F-132-9;



e) Elk Meat, New York Strip Steak, Chilled. Item number 755128, Recall #
F-133-9;



f) Elk Meat, Flank Steak Frozen. Item number 755131, Recall # F-134-9;


CODE


Elk Meats with production dates of December 29, 30, and 31


RECALLING FIRM/MANUFACTURER


Recalling Firm: Sierra Meats, Reno, NV, by telephone on January 29, 2009 and
press release on February 9, 2009.


Manufacturer: Noah's Ark Holding, LLC, Dawson, MN. Firm initiated recall is
ongoing.


REASON


Elk products contain meat derived from an elk confirmed to have Chronic
Wasting Disease (CWD).


VOLUME OF PRODUCT IN COMMERCE


Unknown


DISTRIBUTION


NV, CA, TX, CO, NY, UT, FL, OK


___________________________________




http://www.fda.gov/bbs/topics/ENFORCE/2009/ENF01099.html




old news. ...

http://www.mad-cow.org/00/dec00_late_news.html#hhh

http://www.mad-cow.org/00/jan01_late.html#ggg

http://www.organicconsumers.org/meat/elkvelvet.cfm

Terry S. Singeltary Sr. [[email protected]] ... CJDIBSE (aka madcow) Human/Animal TSE's--U.S.--Submission .... such as 'nutritional supplements' containing various extracts ... US cattle/sheep/cervids. ("antler velvet" extracts!) should be forbidden ... suggest that CWD transmissions to humans would be as limited ...

http://www.fda.gov/ohrms/dockets/ac/01/slides/3681s2_09.pdf

Volume 361, Number 9368 03 May 2003

Correspondence

Tighter regulation needed for dietary supplements in USA

Sir--Mary Palmer and colleagues (Jan 11, p 101)1 found that dietary supplements have the potential to cause serious adverse effects. The investigators state that research on the hazards and risks ofdietarysupplements should be a priority. The safety of individuals who consume these products is important, and organisations such as the US Food and Drug Administration (FDA) need to take initiative by enforcing stricter regulations on supplements. Several commonly used products--for example ginkgo biloba, St John's Wort, and ephedrine--can have serious adverse effects.2 Although the FDA requires multiple studies on the safety and efficacy for pharmaceutical products before placing them on the market, standards are less robust for dietary supplements. In the USA, under the Dietary Supplement Health and Education Act (DSHEA) of 1994, supplements are subject to the same regulatory requirements as food. There are no provisions that require FDA approval for the safety or effectiveness of supplements,3 which leaves consumers and manufacturers essentially responsible for the health effects of these products. The DSHEA of 1994 needs to be revised so that dietary supplements are subject to the same regulations as pharmacological drugs. The FDA needs to review clinical studies on the safety and efficacy of dietary supplements. Organisations such as Public Citizen and the American Medical Association are already taking steps to achieve these changes. However, they face immense opposition from groups such as the National Nutritional Foods Association, the American Herbal Association, and the Council for Responsible Nutrition. To overcome such resistance, consumer organisations, health-care providers, and government agencies need to approach this subject in unison. The public needs to be able to assess the risks and benefits of dietary supplements before consuming them. Health-care providers and the more than 100 million Americans who consume these products4 should encourage the FDA to treat supplements with the stringent regulations it enforces on pharmaceutical products.

Nipa Kinariwala ------------------------------------------------------------------------ 700 Bolinwood Drive, Apartment 12A, Chapel Hill, NC 27514, USA 1 Palmer ME, Haller C, McKinney PE, et al. Adverse events associated with dietary supplements: an observational study. Lancet 2003; 361: 101-06. [Text <http://www.thelancet.com/journal/vol361/iss9368/full/llan.361.9352.original_research.23936.1>] 2 Cupp MJ. Herbal remedies: adverse effects and drug interactions. Am Fam Physician 1999; 59: 1239-45. [PubMed <http://www.ncbi.nlm.nih.gov/htbin-post/PubMed/wgetcit?journal=Am+Fam+Physician+&volume=59&year=1999&page=1239&display=abstract>] 3 Unites States Food and Drug Administration. Overview of dietary supplements. Jan 3, 2001. http://www.cfsan.fda.gov/~dms/ds-oview.html <http://www.cfsan.fda.gov/%7Edms/ds-oview.html%20>(accessed Feb 20, 2002). 4 Pear R. Feds call for tighter control over nutritional supplements. Organic Consumers Association, April 17, 2001. http://www.organicconsumers.org/Organic/dietsupp.cfm <http://www.organicconsumers.org/Organic/dietsupp.cfm%20>(accessed Feb 20, 2002). http://www.thelancet.com/journals/lancet/article/PIIS0140673603132072/fulltext

==================================================

TSEs i.e. mad cow disease's BSE/BASE and NUTRITIONAL SUPPLEMENTS

IPLEX, mad by standard process;

vacuum dried bovine BRAIN, bone meal, bovine EYE, veal Bone, bovine liver powder, bovine adrenal, vacuum dried bovine kidney, and vacuum dried porcine stomach.

also;

i will only list animal ingredients of the following Nutritional Supplements by only ONE company;

Standard Process Co.

IPLEX; bovine EYE PMG Extract, veal bone PMG Extract, bovine liver powder, vaccuum dried porcine stomach, vacuum dried bovine adrenal, vacuum dried bovine kidney, bovine adrenal, vacuum dried BOVINE BRAIN, bone meal, vacuum dried veal bone.

A-FBetafood R vacuum dried bovine prostate, bovine liver powder, vacuum dried bovine kidney, bovine orchic glandular extract, bovine liver fat extract.

Arginex R bovine liver powder.

Adrenal, Desiccated TM Vacuum dried bovine adrenal.

Albaplex R bovine liver PMG Extract, vacuum dried bovine adrenal, bovine kidney PMF Extract, bovine thymus Cytosol Extract, bovine liver powder, bone meal, vacuum dried bovine kidney, veal bone meal.

Allerplex TM bovine lung PMF Extract, bovine adrenal PMF Extract, bovine liver fat extract (yakriton), bone meal, vacuum dried bovine kidney, vacuum dried veal bone.

Immuplex R Bovine liver PMG Extract, bovine liver powder, veal bone PMF Extract, bovine spleen PMF Extract, vacuum dried bovine and ovine spleen, bovine thymus PMF Extract, bovine thymus Cytosol Extract.

Vasculin R Bovine Heart PMG Extract, veal bone PMF Extract, bovine liver powder, vacuum dried porcine duodenum, bovine adrenal Cytosol Extract, vacuum dried bovine and ovine spleen.

Zypan R bovine pancreas Cytosol Extract, vacuum dried bovine and ovine spleen.

last i heard, they were getting sued;

Suit Filed Over Mad Cow Disclaimer

By Jason Hoppin The Recorder March 23, 2001

A small San Francisco litigation firm has teamed up with Milberg, Weiss, Bershad, Hynes & Lerach to sue a health supplements manufacturer, alleging the company misrepresents the danger of acquiring mad cow disease through its products.

The suit, filed under California's unfair business practices statute, alleges that Wisconsin's Standard Process Inc. uses, in part, crackpot science to allay customers' fears about the transmission of bovine spongiform encephalopathy, also known as mad cow disease.

"Standard Process either knowingly or recklessly has omitted a material fact by failing to inform consumers that the overwhelming majority of reputable scientists and physicians have concluded that mad-cow disease is transmitted to humans by prions in bovine meat and/or bovine organs," Bushnell, Caplan & Fielding's Alan Caplan wrote.

The complaint points to a statement by the company about the safety of its products which suggests that pesticides may be to blame for mad cow outbreaks, not the consumption of meat.

"It's probably loosely referred to as research," deadpanned Jan Novakofski, a University of Illinois researcher who studies thedisease. "The evidence for that kind of concept [versus the consumption theory] is about an ounce to a pound."

No cases of mad cow have ever been reported in the United States, and the plaintiff in the case, James Gorman, does not suffer from the disease. Instead, he is seeking damages for misrepresentation, fraud, unfair advertising and unfair business practices.

The case was filed in San Francisco Superior Court.

The product, a vitamin supplement called Iplex 5100, is sold through licensed health professionals, including acupuncturists, nutritionists and the like.

Iplex 5100 is made in part, with cow parts: eyes, kidneys, livers, bonesand brains, where BSE is most highly concentrated.

Standard Process did not return a phone call seeking comment, but the company's Web site says it purchases bovine products only from U.S.government-inspected facilities.

"Standard Process has never used any glandular substances or bovine tissue derivatives from animals in any BSE-infected country," the company states.

The human manifestation of BSE -- variant Creutzfeld-Jakob disease --has killed more than 80 people in Great Britain, and new outbreaks have recently been reported in several European countries.

U.S. officials have worried that dietary supplements may provide an entry point for the disease, which has been detected here in animals other than cows.

"The health food industry is totally unregulated," Novakofski said. "You go to the health food store and no one's ever tested anything."

However, Standard Process says its Wisconsin production facility is regulated by the U.S. Food and Drug Administration, and that its cow products are certified by the government.

© 2001 law.com Inc. ======================= Supplements Association Moves to Eliminate Bovine Parts From Products

WASHINGTON (Reuters Health) Mar 16 - The nation's largest dietary supplements industry group has issued new guidance to manufacturers amid concerns that some alternative health products containing bovine materials pose a risk of transmitting bovine spongiform encephalopathy (BSE) to humans.

The guidance, published by the National Nutritional Foods Association (NNFA), encourages manufacturers to eliminate all neurological bovine materials from their products. Consumption of brains and spinal cords from cows infected with BSE are widely believed to be the source of new variant Creutzfeldt-Jakob disease (vCJD) in humans........

snip... full text at;

http://id.medscape.com/

Letter to Manufacturers of Biological Products - Recommendations Regarding Bovine Spongiform Encephalopathy (BSE)

Department of Health and Human Services Public Health Service Food and Drug Administration 1401 Rockville Pike Rockville, MD 20852-1448

April 19, 2000

To Manufacturers of Biological Products

The Food and Drug Administration (FDA) has issued letters (date May 3, 1991, December 17, 1993, and May 9, 1996) and a guidance document (September 1997) requesting that materials derived from ruminants which have resided in or originated from countries where Bovine Spongiform Encephalopathy (BSE) has been diagnosed not be used in the manufacture of FDA-regulated products intended for administration to humans. The United States Department of Agriculture (USDA) also issued an interim rule on January 6, 1998, restricting the importation of ruminants, meat and meat products from ruminants, and certain ruminant products and byproducts from all countries of Europe. Because of the serious nature of this issue, the Center for Biologics Evaluation and Research (CBER) believes it critical to update the current recommendations.

CBER strongly recommends that manufacturers take whatever steps are necessary to assure that materials derived from all species of ruminant animals born, raised or slaughtered in countries where BSE is known to exist, or countries where the USDA has been unable to assure FDA that BSE does not exist, are not used in the manufacture of FDA-regulated products intended for administration to humans. The Agency has previously recommended that manufacturers take the following steps to prevent this occurrence:

1.Identify all ruminant-derived materials (e.g., culture medium, transferrin, albumin, enzymes, lipids) used in the manufacture of regulated products. FDA considers the manufacture of biological products to include the preparation of master (including the original cell line) and working cell banks, as well as materials used in fermentation, harvesting, purification and formulation of the products.

2.Document the country of origin and all countries where the live animal source has resided for each ruminant-derived material used in the manufacture of the regulated product. The regulated-product manufacturer should obtain this information from the supplier of the ruminant-derived product. The regulated-product manufacturer should also obtain the appropriate veterinary regulatory inspection certification of slaughter, as required by the country of origin of live animals, from the supplier. Documentation should be maintained for any new or in-process lots of licensed, cleared or approved products; products pending clearance or approval; and investigational products intended to be administered to humans.

3.Maintain traceable records for each lot of ruminant material and each lot of FDA-regulated product manufactured using these materials. These records should be part of the product batch records and available for FDA inspection. Such records should be maintained for products manufactured at foreign as well as domestic facilities.

It is the responsibility of the manufacturer to obtain up-to-date information regarding countries where BSE is known to exist, or countries where the USDA has been unable to assure FDA that BSE does not exist. This information is available from the USDA's Animal and Plant Health Inspection Service (APHIS) at telephonenumber 301-734-8364, website addresshttp://www.aphis.usda.gov/ncie, and codified at 9 CFR 94.18 (see attached).

Specific product-related questions should be directed to the appropriate application division within CBER's product offices. The phone numbers are:

Dr. David Asher, Office of Blood Research and Review 301-827-3524 Dr. Paul Richman, Office of Vaccines Research and Review 301-827-3070 James Crim, Office of Therapeutics Research and Review 301-827-5101

Thank you for your attention to this matter.

Sincerely,

Kathryn C. Zoon, Ph.D. Director Center for Biologics Evaluation And Research

Attachment

http://www.fda.gov/cber/ltr/bse041900.htm

better late than never, but leaving regulation up to the industry, will be like telling the wolf to guard the hen house. allowing that to happen with some pathogens is one thing, but we better think twice about human/animal TSE's. This same letter has been around for ten years with nobody taking heed to the potential dangers...TSS

How serious is this bit of deregulation? Here's what Dr. Lurie told the Senators:"For BSE (mad cow disease), this means that an unscrupulous manufacturer could literally take a British cow brain, crush it, dry it out, formulate it into a dietary supplement and export it to the U.S."

http://commerce.senate.gov/hearings/0404lur.PDF

another fine example;

snip...

In fact, the salesman now tells us he doesn't sell the machines anymore. But the quest for youth goes beyond facial creams and exotic contraptions, anti-agers are also ingesting some pretty wild-sounding dietary supplements. "Live proteins from sheep and pig from France, processed," says a representative.

Life-Cell Technologies touts the benefits of supplements that contain processed pig and sheep organs. "I have a lot of body builders and professional athletes that use these products because they strengthen and stimulate the different glands and organs,"says one woman. The idea, she implied, often is that ingesting ground up animal organs will strengthen human organs or even cure thyroid and adrenal diseases. "To my knowledge you can't just take pulverzied organs and feed them to somebody and think they're not going to have thyroid disease anymore or hypo-adrenalism," says Dr. Wexler. It would be kind of a medical miracle, wouldn't it? "It would be amazing, truly amazing," says Dr. Wexler. "Dateline" attended another anti-aging conference and expo in Chicago -- this time with ourcameras in plain view. Remember the exhibitor selling processed pig and sheep organs? We pressed her for scientific documentation. We asked, what is the science behind the idea? The woman tells us, "You would have to go on the Internet and get information, scientific studies."But this is her company, isn't it? "Yes it is," she says. "And if you don't mind, I don't want to be interviewed. I don't.""Dateline" tells her, "They are simple questions that any consumer would ask." Everywhere "Dateline" went at the anti-aging expo we heard a lot about so-called "scientific studies." "Well, it comes from 3,000 studies," a man at the expo tells us.

At one booth the product is called transfer factor, and theactive ingredient is colostrum -- the potent pre-milk fluid in a lactating mother's breast.

"We actually filtrate the transfer factor out of the colostrum," says one man. From where, mothers? "No," the man tells us. "From bovine colostrum, from cows."

http://www.msnbc.com/news/550100.asp?cp1=1 (url now dead...tss)

AS you can see below, i was trying to warn the public of this potential and highly likely route of TSE via nutritional supplements years before the above people were. THESE folks have PhDs, so maybe someone will listen now, maybe not $$$

Could you get mad cow from a pill ? Some doctors say a class of pills that promise smarts, energy, and sexual vitality may cause mad-cow disease. The government isn't worried. Should you be?

June 1, 2001 Health Magazine by Susan Freinkel

http://www.organicconsumers.org/madcow/pill6101.cfm

http://www.islandveg.com/publications/newsletters/01fall.pdf

GERMAN DER SPIEGEL MAGAZINE

Die BSE-Angst erreicht Amerika: Trotz strikter Auflagen gelangte in Texas verbotenes Tiermehl ins Rinderfutter - die Kontrollen der Aufsichtsbehörden sind lax.

http://www.spiegel.de/spiegel/0,1518,119306,00.html

MAD COW DISEASE AND NUTRITIONAL SUPPLEMENTS...

Subj: cjd/bse aka MADCOW DISEASE in the U.S.A., please let me count the ways...

Date: 31/07/00 17:51:30 GMT Daylight Time

SOMETHING TO CHEW ON

http://www.bmj.com/cgi/eletters/319/7220/1312/b#EL2

In reading the recent article in the BMJ about the potential BSE tests being developed in the U.S. and Bart Van Everbroeck reply. It does not surprize me, that the U.S. has been concealing vCJD. There have been people dying from CJD, with all the symptoms and pathological findings that resemble U.K. vCJD for some time. It just seems that when there is one found, they seem to change the clerical classification of the disease, to fit their agenda. I have several autopsies, stating kuru type amyloid plaques, one of the victims was 41 years of age. Also, my Mom died a most hideous death, Heidenhain Variant Creutzfeldt Jakob disease. Her symptoms resemble that of all the U.K. vCJD victims. She would jerk so bad at times, it would take 3 of us to hold her down, while she screamed "God, what's wrong with me, why can't I stop this." 1st of symptoms to death, 10 weeks, she went blind in the first few weeks. But, then they told me that this was just another strain of sporadic CJD. They can call it what ever they want, but I know what I saw, and what she went through.

Sporadic, simply means, they do not know. My neighbors Mom also died from CJD. She had been taking a nutritional supplement which contained the following; vacuum dried bovine BRAIN, bone meal, bovine EYE, veal bone, bovine liver powder, bovine adrenal, vacuum dried bovine kidney, and vacuum dried porcine stomach. As I said, this woman taking these nutritional supplements, died from CJD. The particular batch of pills that was located, in which she was taking, was tested. From what I have heard, they came up negative, for the prion protein. But, in the same breath, they said their testing, may not have been strong enough to pick up the infectivity. Plus, she had been taking these type pills for years, so, could it have come from another batch?

snip...end

http://www.freedomtocare.org/page142.htm

Evidence Of CJD/BSE Transmission Via Supplements From Terry S. Singeltary Sr. [email protected] 1-26-3

http://www.rense.com/general34/evidenBSE.htm

Scrapie (Mad Sheep Disease) May Pose a Risk to Humans From New Scientist magazine (UK) Online News March 28, 2001

Suspect symptoms

What if you can catch old-fashioned CJD by eating meat from a sheep infected with scrapie?

Exclusive from New Scientist magazine

http://www.organicconsumers.org/meat/scrapiecjd.cfm

Singeltary suspected an environmental cause in his mother's demise, a feeling reinforced a year later when a neighbor died of sporadic CJD. For years, the neighbor had been taking nutritional supp- lements that contained cow brain extracts.

"The FDA needs to review clinical studies on the safety and efficacy of dietary supplements. Organisations such as Public Citizen and the American Medical Assoc- iation are already taking steps to achieve these changes.

"However, they face immense opposition from groups such as the National Nutritional Foods Association, the American Herbal Association, and the Council for Responsible Nutrition.

"To overcome such resistance, consumer organisations, health-care providers, and government agencies need to approach this subject in unison. The public needs to be able to assess the risks and benefits of dietary supp- lements before consuming them.

Health-care providers and the more than 100 million Americans who consume these products should encourage the FDA to treat supplements with the stringent regulations it enforces on pharmaceutical products."

Animal ingredients of Nutritional Supplements by only ONE company;

Standard Process Co.

IPLEX;

bovine EYE PMG Extract, veal bone PMG Extract, bovine liver powder, vaccuum dried porcine stomach, vacuum dried bovine adrenal, vacuum dried bovine kidney, bovine adrenal, vacuum dried BOVINE BRAIN, bone meal,vacuum dried veal bone.

A-FBetafood R

vacuum dried bovine prostate, bovine liver powder, vacuum dried bovine kidney, bovine orchic glandular extract, bovine liver fat extract.

Arginex R

bovine liver powder, Adrenal, Desiccated TM, Vacuum dried bovine adrenal.

Albaplex R

bovine liver PMG Extract, vacuum dried bovine adrenal, bovine kidney

PMF Extract, bovine thymus Cytosol Extract, bovine liver powder, bone meal, vacuum dried bovine kidney, veal bone meal.

Allerplex TM

bovine lung PMF Extract, bovine adrenal PMF Extract, bovine liver fat extract (yakriton), bone meal, vacuum dried bovine kidney, vacuum dried veal bone.

Immuplex R

Bovine liver PMG Extract, bovine liver powder, veal bone PMF Extract, bovine spleen PMF Extract, vacuum dried bovine and ovine spleen, bovine thymus PMF Extract, bovine thymus Cytosol Extract.

Vasculin R

Bovine Heart PMG Extract, veal bone PMF Extract, bovine liver powder, vacuum dried porcine duodenum, bovine adrenal Cytosol Extract, vacuum dried bovine and ovine spleen.

WASHINGTON (Reuters Health) Mar 16 2001 - The nation's largest dietary supplements industry group has issued new guidance to manufacturers amid concerns that some alternative health products containing bovine mate- rials pose a risk of transmitting bovine spongiform encephalopathy (BSE) to humans.

The guidance, published by the National Nutritional Foods Association (NNFA), encourages manufacturers to eliminate all neuro- logical bovinematerials from their products. Consumption of brains and spinal cords from cows infected with BSE are widely believed to be the source of new variant Creutzfeldt-Jakob disease (vCJD) in humans.

We hope that the above data informs, but not overwhelms, the reader. For the technically literate there are numerous articles and links available via. www.google.com (http://www.google.com) searching for mad cow disease. If you have any questions for

Terry Singeltary write or e-mail [email protected] and we will forward them to him.

http://www.organicconsumers.org/madcow/supplements11004.cfm

Docket Management Docket: 96N-0417 - Current Good Manufacturing Practice in Manufacturing, Packing, or Holding Dietary Ingredients a Comment Number: EC -2 Accepted - Volume 7

snip...

what did Paul Brown say about this previously;

i bring your attention to (page 500) Dr. Paul Brown statements;

253 1 DR. BOLTON: I have an additional question about 2 that. What is the assurance that additional locally sourced 3 tracheas are not added into that manufacturing process, thus 4 boosting the yield, if you will, but being returned to the 5 U.S. as being produced from U.S.-sourced raw material? 6 DR. McCURDY: Are there data to indicate how many 7 grams, or whatever, of infected brain are likely to infect 8 an organism, either animal or man, when taken orally? 9 DR. BROWN: If I am not mistaken, and I can be 10 corrected, I think a half a gram is enough in a cow, orally; [FULL TEXT ABOUT 600 PAGES] 3681t2.rtf

http://www.fda.gov/ohrms/dockets/ac/cber01.htm

snip...

http://www.fda.gov/OHRMS/DOCKETS/DOCKETS/96n0417/96N-0417-EC-2.htm

Unregulated "foods" such as 'nutritional supplements' containing various extracts from ruminants, whether imported or derived from 3 US cattle/sheep/cervids ("antler velvet" extracts!) should be forbidden or at least very seriously regulated.

(neighbors Mom, whom also died from CJD, had been taking bovine based supplement, which contained brain, eye, and many other bovine/ovine tissues for years, 'IPLEX').

http://www.fda.gov/OHRMS/DOCKETS/AC/01/slides/3681s2_09.pdf

my plight with metabolife and there 'bovine complex' about risk factors of TSE in there product ;

Terry S. Singeltary Sr. wrote:

######## Bovine Spongiform Encephalopathy <BSE-L at UNI-KARLSRUHE.DE> #########

1. Dietary Supplements: Review of Health-Related Call Records for Users of Metabolife 356. GAO-03-494, March 31.

http://www.gao.gov/cgi-bin/getrpt?GAO-03-494 http://www.gao.gov/highlights/d03494high.pdf

-------- Original Message --------

Subject: METABOLIFE AND TSEs GAO-03-494 ''URGENT DATA'' Date: Thu, 01 May 2003 11:23:01 -0500 From: "Terry S. Singeltary Sr." <flounder at wt.net> To: NelliganJ at gao.gov

The General Accounting Office (GAO) today released the following reports and testimonies:

REPORTS

1. Dietary Supplements: Review of Health-Related Call Records for Users of Metabolife 356. GAO-03-494, March 31.

http://www.gao.gov/cgi-bin/getrpt?GAO-03-494 http://www.gao.gov/highlights/d03494high.pdf

GREETINGS GAO:

i was suprised that i did not see any listing of bovine tissue in metabolife on it's label. have they ceased using these desiccated tissues???

i see that the lable on this product METABOLIFE 356, does not state that it has any tissues of desiccated bovine organs? i no the product use to, so i am curious if they have ceased the use of the tissues of cattle they _use_ to use (see below)???

METABOLIFE 356 BOVINE COMPLEX/GLANDULAR SYSTEM OVARIES, PROSTATE, SCROTUM AND ADRENAL USDA SOURCE CATTLE

i tried warning them years ago of this potential threat of CJD/TSEs;

From: Randy Smith To: "'flounder at wt.net'" Subject: Metabolife Date: Mon, 7 Dec 1998 14:21:35 -0800

Dear Sir,

We are looking at reformulation. I agree that slow virus diseases present a problem in some areas of the world.

Our product uses healthy USDA inspected cattle for the glandular extract.

If you have any links to more information on this subject I would like to examine them.

Thank you for your interest and concern,

Dr. Smith ============

From: Randy Smith To: "'flounder at wt.net'" Subject: RE: [Fwd: Your submission to the Inquiry] Date: Wed, 9 Dec 1998 10:37:07 -0800

Terry,

Thank you for your note and the information links you forwarded to me. I am new to Metabolife International, however hopefully as my role here enlarges I well have a greater impact on formulation and product development.

Metabolife International does believe in placing safety first. And I am going to do my best to see that we continue to do so.

Sincerely, Dr. Smith ============ -----Original Message----- From: Terry S. Singeltary Sr. [mailto:flounder at wt.net] Sent: Wednesday, December 09, 1998 5:49 PM To: rsmith at metabolife.com Subject: [Fwd: Your submission to the Inquiry]

Dr. Smith, I am truly impressed with you honesty, THANKS.....I am not just spouting off about the potential dangers, here. THEY ARE REAL.....I have forwarded an e-mail from the BSE Inquiry, in which I made a statement about them........You might want to go to the site and read through it........IT WILL TAKE A WHILE........ THINGS ARE HAPPENING HERE SIR, THAT YOU ARE NOT AWARE OF, AND AS MOST PEOPLE ARE NOT...............I JUST HOPE, THAT THE REFORMULATION YOU SPEAK OF, IS IN FACT GOING TO TAKE PLACE. The Department of Health, here in the U.S., is also worried about the potential dangers involved hear............Terry/MADSON

================================================== =======

From: Randy Smith To: "'flounder at wt.net'" Subject: RE: [Fwd: MEDICINES "GREATER BSE RISK THAN BEEF"!!!!] Date: Fri, 18 Dec 1998 09:55:17 -0800 Return-Receipt-To: Randy Smith

Thanks very much for the info. I appreciate all these articles I can get. It does sound very familiar - just follow the green ($) trail.

-----Original Message----- From: Terry S. Singeltary Sr. [mailto:flounder at wt.net] Sent: Friday, December 18, 1998 5:15 PM To: rsmith at metabolife.com Subject: [Fwd: MEDICINES "GREATER BSE RISK THAN BEEF"!!!!]

Randy, thought you might be interested in this...............MADSON!!!!!1

snip... ===============================

Sender: "Patricia Cantos" <patricia.cantos at bse.org.uk> To: "Terry S Singeltary Sr. (E-mail)" <flounder at wt.net> Subject: Your submission to the Inquiry Date: Fri, 3 Jul 1998 10:10:05 +0100

3 July 1998 Mr Terry S Singeltary Sr. E-Mail: Flounder at wt.net Ref: E2979

Dear Mr Singeltary,

Thank you for your E-mail message of the 30th of June 1998 providing the Inquiry with your further comments. Thank you for offering to provide the Inquiry with any test results on the nutritional supplements your mother was taking before she died.

As requested I am sending you our general Information Pack and a copy of the Chairman's letter. Please contact me if your system cannot read the attachments.

Regarding your question, the Inquiry is looking into many aspects of the scientific evidence on BSE and nvCJD. I would refer you to the transcripts of evidence we have already heard which are found on our internet site at http://www.bse.org.uk. Could you please provide the Inquiry with a copy of the press article you refer to in your e-mail? If not an approximate date for the article so that we can locate it? In the meantime, thank you for you comments. Please do not hesitate to contact me on 0171 261 8332 should you have any queries.

Yours sincerely Patricia Cantos Families Team Leader Attachments TSS

==============

-------- Original Message --------

Subject: re: METABOLIFE AND TSEs GAO-03-494 ''URGENT DATA'' Date: Thu, 01 May 2003 16:04:35 -0400 From: "Marcia G Crosse" <CrosseM at gao.gov> To: <flounder at wt.net> CC: "Charles W Davenport" <DavenportC at gao.gov>, "Carolyn Feis Korman" <FeisKormanC at gao.gov>, "Martin Gahart" <GahartM at gao.gov>

Mr. Singletary,

We were informed by representatives of Metabolife, Inc. that Metabolife 356 was reformulated to remove bovine complex as an ingredient in the product, approximately September 2001. We did not independently verify the contents of the product.

Sincerely, Marcia Crosse Acting Director Health CarePublic Health and Science Issues U.S. General Accounting Office 441 G Street, N.W. Washington, D.C. 20548

===================

-------- Original Message -------- Subject: Re: METABOLIFE AND TSEs GAO-03-494 ''URGENT DATA'' Date: Thu, 01 May 2003 15:48:52 -0500 From: "Terry S. Singeltary Sr." <flounder at wt.net> To: Marcia G Crosse <CrosseM at gao.gov> CC: Charles W Davenport <DavenportC at gao.gov>, Carolyn Feis Korman <FeisKormanC at gao.gov>, Martin Gahart <GahartM at gao.gov> References: <seb14599.014 at GAOGWIA1.GAO.GOV>

THANK YOU!

MIRACLES DO HAPPEN! ;-)

now all we need to do is;

snip......

one small step for man, one giant leap for mankind ;-)

however;

''We did not independently verify the contents of the product''

???

TSS

####### http://mailhost.rz.uni-karlsruhe.de/warc/bse-l.html ########

-------- Original Message --------

Subject: DOCKET-- 03D-0186 -- FDA Issues Draft Guidance on Use of Material From Deer and Elk in Animal Feed; Availability Date: Fri, 16 May 2003 11:47:37 -0500 From: "Terry S. Singeltary Sr." <[email protected]> To: [email protected]

Greetings FDA,

i would kindly like to comment on; Docket 03D-0186FDA Issues Draft Guidance on Use of Material From Deer and Elk in Animal Feed; Availability Several factors on this apparent voluntary proposal disturbs me greatly, please allow me to point them out;

snip...

Oral transmission and early lymphoid tropism of chronic wasting diseasePrPres in mule deer fawns (Odocoileus hemionus ) These results indicate that CWD PrP res can be detected in lymphoid tissues draining the alimentary tract within a few weeks after oral exposure to infectious prions and may reflect the initial pathway of CWD infection in deer. The rapid infection of deer fawns following exposure by the most plausible natural route is consistent with the efficient horizontal transmission of CWD in nature and enables accelerated studies of transmission and pathogenesis in the native species.

snip...

http://vir.sgmjournals.org/cgi/content/full/80/10/2757

now, just what is in that deer feed? _ANIMAL PROTEIN_

Subject: MAD DEER/ELK DISEASE AND POTENTIAL SOURCES

Date: Sat, 25 May 2002 18:41:46 -0700 From: "Terry S. Singeltary Sr." Reply-To: BSE-LTo: BSE-L

8420-20.5% Antler DeveloperFor Deer and Game in the wildGuaranteed Analysis Ingredients / Products Feeding Directions

snip...

_animal protein_

http://www.surefed.com/deer.htm

snip...

DEPARTMENT OF HEALTH & HUMAN SERVICESPUBLIC HEALTH SERVICEFOOD AND DRUG ADMINISTRATIONApril 9, 2001 WARNING LETTER01-PHI-12CERTIFIED MAILRETURN RECEIPT REQUESTED

Brian J. Raymond, Owner Sandy Lake Mills 26 Mill Street P.O. Box 117 Sandy Lake, PA 16145

PHILADELPHIA DISTRICT

Tel: 215-597-4390

Dear Mr. Raymond:Food and Drug Administration Investigator Gregory E. Beichner conducted an inspection of your animal feed manufacturing operation, located in Sandy Lake, Pennsylvania, on March 23,2001, and determined that your firm manufactures animal feeds including feeds containing prohibited materials. The inspection found significant deviations from the requirements set forth in Title 21, code of Federal Regulations, part 589.2000 - Animal Proteins Prohibited in Ruminant Feed. The regulation is intended to prevent the establishment and amplification of Bovine Spongiform Encephalopathy (BSE) . Such deviations cause products being manufactured at this facility to be misbranded within the meaning of Section 403(f), of the Federal Food, Drug, and Cosmetic Act (the Act).Our investigation found failure to label your swine feed with the required cautionary statement "Do Not Feed to cattleor other Ruminants" The FDA suggests that the statement be distinguished by different type-size or color or other means of highlighting the statement so that it is easily noticed by a purchaser.

In addition, we note that you are using approximately 140 pounds of cracked corn to flush your mixer used in the manufacture of animal feeds containing prohibited material. This flushed material is fed to wild game including deer, a ruminant animal.Feed material which may potentially contain prohibited material should not be fed to ruminant animals which may become part of the food chain.The above is not intended to be an all-inclusive list of deviations fromthe regulations. As a manufacturer of materials intended for animalfeed use, you are responsible for assuring that your overall operation and the products you manufacture and distribute are in compliance withthe law. We have enclosed a copy of FDA's Small Entity Compliance Guideto assist you with complying with the regulation... blah, blah, blah...

http://www.fda.gov/foi/warning_letters/g1115d.pdf

snip...end...full text ;

2003D-0186 Guidance for Industry: Use of Material From Deer and Elk In Animal Feed

EMC 1 Terry S. Singeltary Sr. Vol #: 1

http://www.fda.gov/ohrms/dockets/dailys/03/Jun03/060903/060903.htm

http://www.fda.gov/ohrms/dockets/dailys/01/Oct01/101501/101501.htm

see my full text submission here ;

http://madcowfeed.blogspot.com/2008/07/docket-03d-0186-fda-issues-draft.html

Saturday, January 24, 2009

Research Project: Detection of TSE Agents in Livestock, Wildlife, Agricultural Products, and the Environment Location: 2008 Annual Report

http://bse-atypical.blogspot.com/2009/01/research-project-detection-of-tse.html

Friday, November 30, 2007

CJD QUESTIONNAIRE USA CWRU AND CJD FOUNDATION

snip...

*** NOTE ***

please include venison/sheep/lamb and the bovine to any of the above questions.

example=brain tanning deer/elk hide or any other topics that pertain to transmission of TSEs

_________________________________________________

example=antler velvet nutritional supplements

_________________________________________________

_any_ nutritional supplements??? name/ingredients

_________________________________________________

snip...

http://cjdquestionnaire.blogspot.com/

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518

http://cjdquestionnaire.blogspot.com/

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518


Thursday, March 19, 2009
Chronic Wasting Disease Prions in Elk Antler Velvet (Nutritional Supplements and CJD)


http://chronic-wasting-disease.blogspot.com/2009/03/chronic-wasting-disease-prions-in-elk.html