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NIH finds clue to what makes prions kill

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rkaiser

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:roll: Come on Reader(the second) your'e getting desperate for material aren't you?

This research is a complete waste of time, and your writer is a complete a$$.

Her quote - "Related diseases - including mad cow, scrapie in sheep and the human Creutzfeldt-Jakob disease - are believed to arise when a protein the body normally harbors folds into an abnormal shape, called a prion, and sets off a chain reaction of misfolds." is so far off base that even you must see the faults in it.
 

rkaiser

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:) Someone may have a breakthrough that WILL save lives and you scoff.

Mark Purdey's theory is being exploited by scientist all over the world with no credit to the man whose work will someday prove that all of this other research is for not. AND YOU SCOFF.

I may be low, Reader(the second) but you are the worm beneath me.

If I am not understanding something about this NEW information forgive my ignorance, but connecting this NEW stuff to a writer who is less educated about the basic principles of prion research makes the whole article difficult to finish.

Educate me reader(the second). explain to me how injecting these mice (once again) with contaminated breain material has anything to do with transmission, or the dreaded species leap, that everyone is so bound to prove yet none have even come close.
 

rkaiser

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My goodness, I tried to read that garbage again and couldn't even get past the second sentence.

"These mysterious substances must latch on to the outside of cell membranes to be toxic."

Prions are a naturally occuring protein and have a purpose. It is when these prions are exposed on the cell surface and become a misfolded prion that they become a problem. This misfolding is caused when the wrong "rouge metals" are attracted to the prion.

This little bit of "Alberta rancher interpreted" information may be simple, but is not argued in the scientific community.

If this information spent anywher near the time on the bench of scientists around the world as the "find a cure studies" we would not have to waste near as much time finding the ultimate solution. The probelm is reader, all the folks looking for solutions have no proof of cause with which to begin their research.

Mysterious substances my butt. Come on reader find another example at the very least.
 

rkaiser

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Okay reader, discuss this with me.

First of all they are creating mice that lack the glue that holds the prion in place on the cell wall. Fine for experimental purpose when they are looking for something beyond.

Sure would be hard to deal with genetically engineering cattle to lack this glue (avoiding BSE) when the truth about the natural purpose of functioning prion is not known. (or not admitted to be known).

Okay, I will give that the purpose of this genetically engineered mouse is for further study.

Now what. Find a drug that disrupts the process of the prion.

Tell me what you think reader. Does the normal functioning prion have a purpose, or would you rather listen to writers like the first one you quoted call them mysterious, or shall we say extraterrestrial?

You folks that follow these Prusiner clones call us the nuts, but you don't even have a clear discription of the prion itself. Sounds a bit like the almond calling the pea - nut.
 

Kathy

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Randy, don't call the healthy PrPC protein a prion, it's not a PRION!!

These genetically modified mice, are they the so-called "knock-out" mice developed that don't produce PrPC proteins, or, are they a new GM mouse that produces only a portion of the natural healthy PrPC protein?

(By the way, if these scientists can reproduce the portion of the prion which causes tranmission of disease, then don't you think they know what the make-up and ingredients are of these prions?? Where is their magic formula?)

Either way, they are not animals which "naturally exist". There usefullness in the lab, is very limited by this.

I imagine a chemical which works something like chemotherapy could be used on people to prevent the anchoring of the PrPC protein to a cell membrane, but, slow down here.

As Randy said, their is a genuine purpose for the healthy PrPC protein, and it has been decribed by Dr. David Brown and others. Brown found that without its natural function, certain enzymatic functions were decreased, and this could cause cell death. What kind of damaging effects would occur to the brain if it was starved of the natural function of the PrPC protein? The knock-out mice, didn't fair so well in the lab. Being alive doesn't mean they are healthy.

Some chemo's, like the one I had, caused the fastest growing cells in my body to be damaged/killed and this stopped the rapid growth of the cancer cells (hopefully). Most, but not all malignant cells grow faster than our other healthy cells. Hair falls out because it is one of the fastest growing proteins. Luckily, this damage was short term and my hair grew back, although it is now a salt and pepper color.

Could a therapy that blocked PrPSc attachment to cell membranes work? Interesting question, but, as Randy pointed out the damage to the cell occurs with the accummulation of the prion on the cell, basically suffocating it of its nutrients.

Accummulation of plaques which cannot cause transmission, verses plaques which do, is an extremely important field of research.

Working with genetically modified animals with the intent to adapt this to the cattle industry is horrific. I would be far more concerned about the effects of eating GM foods, than I am about eating prions.

I personally, would prefer to see the research which uses cattle and BSE. I am still confused why experimental transmission studies on mice continue to use the scrapie prion. Surely we can source enough BSE prion from the UK to use in these experiments. Do not scientists like Prusiner, Aguzzi, have formulas for reproducing BSE prions?

I think Randy's points are important and well-said:

If this information spent anywhere near the time on the bench of scientists around the world as the "find a cure studies" we would not have to waste near as much time finding the ultimate solution. The probelm is reader, all the folks looking for solutions have no proof of cause with which to begin their research.

Putting the cart before the horse = no profit, no gain.

This is what has plagued our medical system for years and years. If no one was sick, we wouldn't need doctors, nurses, drugs, hospitals etc.
 

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