mrj said:
Thanks for that information Mike, but wasn't the subject of the thread ANIMAL diseases? Getting into the human disease aspect was confusing in an animal health thread. I thought you had found a disease that crosses species barriers. Can TB do that? I know it occurs both in humans and in cattle, but is it the same, and can it cross both ways?
Still, it is interesting to learn of yet another reason for totally closing that border to illegal immigrants. I'm not sure how I would rate that as compared with the fact that many of the illegals are natives of countries where extremist Islam terrorists are trained. TB probably would rank behind the terrorists because TB can be controlled or cured in some cases.
mrj
Bovine TB, caused by M. bovis, can be transmitted from livestock to humans and other animals. No other TB organism has as great a host range as bovine TB, which can infect all warm blooded vertebrates. M. avium can affect all species of birds, as well as hogs and cattle. M. tuberculosis primarily affects humans but can also be transmitted to hogs, cattle, and dogs.
Bovine TB has affected animal and human health since antiquity.
http://www.aphis.usda.gov/animal_health/animal_diseases/tuberculosis/
Lancet (1991) 338: 1253-5.
Mycobacterium bovis infection in human beings in contact with elk (Cervus elaphus) in Alberta, Canada.
A Fanning, S Edwards
Human infection with Mycobacterium bovis is rare in developed countries because of milk pasteurisation and the slaughter of infected cattle. An epizootic of M bovis infection in domesticated elk (Cervus elaphus) in Alberta, Canada, which started in April, 1990, prompted us to seek human contacts of elk herds. There were 446 identified contacts, in 394 of whom tuberculin skin tests were done. Of 81 contacts who were skin-test positive, 50 had been in contact with culture-positive animals. 6 of 106 subjects tested a second time became tuberculin positive. 1 case of active M bovis infection was diagnosed by sputum culture. The mode of transmission of M bovis from these farm animals to man is likely to be aerosolisation of infected particles. Because of the apparent susceptibility of farmed Cervidae (deer) to M bovis infection, and the evidence of spread to man, control measures to prevent human infection should be developed.
http://www.thelancet.com/journals/lancet/article/PII0140-6736(91)92113-G/abstract
http://www.thelancet.com/
Dispatches
Mycobacterium tuberculosis infection as a Zoonotic Disease: Transmission between Humans and Elephants Kathleen Michalak,* Connie Austin,† Sandy Diesel,* J. Maichle Bacon,* Phil Zimmerman,‡ and Joel N. Maslow§ *McHenry County Department of Health, Woodstock, Illinois, USA; †Illinois Department of Public Health, Springfield, Illinois, USA; ‡University of Illinois, College of Medicine at Rockford, Rockford, Illinois, USA; and §Boston University School of Medicine and the VA Medical Center, Boston, Massachusetts, USA
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Between 1994 and 1996, three elephants from an exotic animal farm in Illinois died of pulmonary disease due to Mycobacterium tuberculosis. In October 1996, a fourth living elephant was culture-positive for M. tuberculosis. Twenty-two handlers at the farm were screened for tuberculosis (TB); eleven had positive reactions to intradermal injection with purified protein derivative. One had smear-negative, culture-positive active TB. DNA fingerprint comparison by IS6110 and TBN12 typing showed that the isolates from the four elephants and the handler with active TB were the same strain. This investigation indicates transmission of M. tuberculosis between humans and elephants.
Mycobacterium tuberculosis and M. bovis, related organisms of the M. tuberculosis complex, infect a wide variety of mammalian species. M. bovis is pathogenic for many animal species, especially bovidae, cervidae, and occasionally carnivores. Human disease with M. bovis is well described and historically was a common cause of tuberculosis (TB) transmitted by infected dairy products. As a result of milk pasteurization and TB eradication programs in most industrialized countries, zoonotic transmission of M. bovis through domestic livestock is now rare. In contrast, a similar eradication program has not been conducted for wild or exotic animals, which therefore remain an uncommon source for M. bovis exposure. Zoonotic transmission of M. bovis has been reported from seals, rhinoceros, and elk (1-4).
M. tuberculosis, the most common species to cause TB, classically causes disease in humans. Animal infection with M. tuberculosis, while uncommon, has been described among species (e.g., birds, elephants, and other mammals) with prolonged and close contact with humans (5-10). Transmission of M. tuberculosis between animals and humans has not been reported. This paper describes M. tuberculosis transmission from elephants to humans.
http://www.cdc.gov/ncidod/eid/vol4no2/michalak.htm
http://www.aphis.usda.gov/animal_health/animal_diseases/tuberculosis/
Mycobacterium tuberculosis is the cause of most of the cases of tuberculosis in humans. Worldwide, more humans die as a result of tuberculosis each year than from any other infectious disease.4 At present, more than a third of the world's population is infected with tubercle bacilli and more people are dying as a result of tuberculosis than ever in history. Ninety-five percent of the tuberculosis cases are reported in developing countries, and it has been estimated that the disease results in the deaths of 2 to 3 million people each year.
snip...
Contact with infected animals is another source of M bovis infection for humans and is a recognized hazard for abattoir workers, veterinarians, and livestock handlers.5- 7,11,15-17 Among such workers who developed the disease, aerosol transmission was considered the most likely route of infection, but there are many occasions on which infection had been spread via cuts and abrasions (eg, butcher's wart).16 Although many of the primary nonaerosol sources of M bovis infection in humans have been removed in industrialized countries, there has been an increase in the number of cases of pulmonary infection with M bovis, which may be due to several factors: the lung is the usual site of postprimary M bovis infection, regardless of the site of the primary lesion; cases of pulmonary M bovis infection may be the result of reactivation of previously quiescent (ie, nonclinical) primary lesions; and infection may be the result of human-tohuman aerosol transmission.16 Finally, aerosol transmission of M tuberculosis from humans to animals has been reported.18,19 The disease has been reported in elephants, nonhuman primates, and several other species.18-22,b The reemergence of M bovis infection in captive and free-ranging wild animals, with subsequent transmission of infection to domestic animals, is of concern to livestock producers and regulatory officials in the United States and in several other countries of the world.23-26 In Michigan, the detection of tuberculosis in deer and other wild animals and the transmission of M bovis infection to beef and dairy herds have threatened the export of breeding stock and semen to other states and to countries outside the United States.26 When an outbreak of tuberculosis in cattle is reported within a state, federal disease control officials remove the state's accredited-free status, causing economic hardships for the state's livestock industries. With the effects of tuberculosis on animal health and zoonotic implications, eradication and control of disease caused by the bacteria that compose the M tuberculosis complex are high priorities. Despite efforts to control tuberculosis since its recognition in antiquity, the disease continues to be a problem in both human and animal populations.
18. Michalak K, Austin C, Diesel S, et al. Mycobacterium tuberculosis infection as a zoonotic disease: transmission between humans and elephants. Emerg Infect Dis 1998;4:2883–2887.
19. Michel AL, Huchzermeyer HFAK. The zoonotic importance of Mycobacterium tuberculosis: transmission from human to monkey. J S Afr Vet Assoc 1998;69:64–65.
20. Morris PJ, Thoen CO, Legendre AM. Pulmonary tuberculosis in an African lion (Panthera leo). J Zoo Wildl Med 1996;27:392–396.
21. Mikota SK, Peddie L, Peddie J, et al. Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus). J Zoo Wildl Med 2001;32:1–16. 22. Oh P, Granich R, Scott J, et al. Human exposure following Mycobacterium tuberculosis infection in multiple animal species in a metropolitan zoo. Emerg Infect Dis 2002;8:1290–1293.
http://www.avma.org/avmacollections/zu/javma_224_5_685.pdf
TSS