Mike
Well-known member
"In, vCJD, prions accumulate not just in the brain and spinal cord but also in the lymphoid tissue, such as tonsils and appendix, suggesting that prions enter the bloodstream. Sheep and rodent studies have shown that prions can be transmitted to healthy animals through blood transfusions from infected animals. (Snip)
Given the evidence that prions are found in blood, prions may be present in any organ including muscle, since all tissues are perfuse with blood. Patrick Bosque (now at University of Colorado's Healthe Science Center) and I found prions in the hind limb of muscles mice at a level approx. 100,000-fold higher than that found in blood. Michael Beekes and his colleagues at the Robert Koch Institute in Berlin discovered high-levels of prions in virtually all skeletal muscles, not just in the hind limbs."
Given the evidence that prions are found in blood, prions may be present in any organ including muscle, since all tissues are perfuse with blood. Patrick Bosque (now at University of Colorado's Healthe Science Center) and I found prions in the hind limb of muscles mice at a level approx. 100,000-fold higher than that found in blood. Michael Beekes and his colleagues at the Robert Koch Institute in Berlin discovered high-levels of prions in virtually all skeletal muscles, not just in the hind limbs."