From: TSS ()
Subject: SEAC 89TH MEETING ON THURSDAY 22ND SEPTEMBER 2005 AGENDA
Date: September 16, 2005 at 8:09 am PST
89th meeting on Thursday 22nd September 2005
http://www.seac.gov.uk/agenda/agen220905.htm
In BSE in cattle there is early infection of the ileum and tonsils, followed by later
infection of the CNS, dorsal root ganglia and trigeminal ganglia. Emerging Japanese
data suggests that there may be infectivity in peripheral nerves in clinical BSE.
http://www.seac.gov.uk/papers/tseroadmap05.pdf
TSE Roadmap - Scientific Opinions Final Version 6 September 2005
Page
1.1.7. SSC Opinion on Chronic Wasting Disease and Tissues that might carry a
risk for Human and Animal Feed Chains, 6-7 March 2003
Theoretical risk for prion transmission to humans consuming products of CWD
affected cervids of all ages cannot be excluded.
Similarly, transmission risk to domestic animals cannot be excluded4.
Early and widespread involvement of tissues in CWD-infected animals does not allow
definition of SRM list, nor to define age limits. Insufficient data to define exclusions or
amendment of any SRM rule on the basis of relative genetic resistance to infection.
Important to be certain that no risk of transmission of CWD from North America to EU
through trade in live cervids or their products.
No scientific data that CWD is present in countries outside North America (except
single import to Korea). However further European surveillance necessary.
1.1.8. SSC Opinion on BSE Risk of Autonomic Nervous System, 6-7 March 2003
Infectivity found in vagus nerve and sympathetic mesenteric ganglia of experimental
animals (mice/hamsters) and sheep infected with scrapie. Experimental data from
cattle insufficient, but infectivity in these tissues has not been shown in cattle5 other
than the inconsistent presence of disease-related PrP in the myenteric plexus
(network of nerve fibres throughout muscle of digestive tract) of cattle during the
Unclear whether scrapie models are applicable to pathogenesis of BSE. Cannot
exclude possibility that other autonomic NS structures carry infectivity in BSEinfected
Recommend collection of tissue samples appropriate to improving understanding role
of PNS and particularly the autonomic NS, from field cases and cattle in
4 See also 1.1.2. Experimental Transmission of Chronic Wasting Disease Agent from
Mule Deer to Cattle by Intracerebral Route, Hamir et al.2005, J Vet Diagn Invest
5 The Japanese Institute for Animal Health has detected Western Blot positives in
peripheral nerves in a fallen bovine. Further results are expected in late 2005/early
TSE Roadmap - Scientific Opinions Final Version 6 September 2005
Page 8 of 18
9 EC FAIR CT97 3308 Project
10 Refers to April 2004 SSC Opinion on oral exposure of humans to BSE agent:
infective dose and species barrier. This refers to small amount of tissue that can
contain an infective dose of BSE agent for cattle and sheep ( < 1 gram of
homogenised brain tissue). 2005 data suggests 1mg is sufficient to infect calves.
SNIP...
TSE Roadmap - Scientific Opinions Final Version 6 September 2005
Page 9 of 18
2.3.2. Unpublished Data from VLA, 2005
Unpublished data from a pressure rendering study indicates that BSE infectivity can
survive in tallow recovered by centrifugation and tallow recovered by solvent
extraction.
http://www.seac.gov.uk/papers/tseroadmap05-app3.pdf
Appendix 4 - A Summary of Opinions from the Spongiform
Encephalopathy Advisory Committee (SEAC)
http://www.seac.gov.uk/papers/tseroadmap05-app4.pdf
Importation of Whole Cuts of Boneless Beef from Japan [Docket No. 05-004-1] RIN 0579-AB93 TSS SUBMISSION
http://docket.epa.gov/edkfed/do/EDKStaffItemDetailView?objectId=090007d480993808
http://docket.epa.gov/edkfed/do/EDKStaffAttachDownloadPDF?objectId=090007d480993808
http://docket.epa.gov/edkfed/do/EDKStaffCollectionDetailView?objectId=0b0007d48096b40d
TSS
Subject: SEAC 89TH MEETING ON THURSDAY 22ND SEPTEMBER 2005 AGENDA
Date: September 16, 2005 at 8:09 am PST
89th meeting on Thursday 22nd September 2005
http://www.seac.gov.uk/agenda/agen220905.htm
In BSE in cattle there is early infection of the ileum and tonsils, followed by later
infection of the CNS, dorsal root ganglia and trigeminal ganglia. Emerging Japanese
data suggests that there may be infectivity in peripheral nerves in clinical BSE.
http://www.seac.gov.uk/papers/tseroadmap05.pdf
TSE Roadmap - Scientific Opinions Final Version 6 September 2005
Page
1.1.7. SSC Opinion on Chronic Wasting Disease and Tissues that might carry a
risk for Human and Animal Feed Chains, 6-7 March 2003
Theoretical risk for prion transmission to humans consuming products of CWD
affected cervids of all ages cannot be excluded.
Similarly, transmission risk to domestic animals cannot be excluded4.
Early and widespread involvement of tissues in CWD-infected animals does not allow
definition of SRM list, nor to define age limits. Insufficient data to define exclusions or
amendment of any SRM rule on the basis of relative genetic resistance to infection.
Important to be certain that no risk of transmission of CWD from North America to EU
through trade in live cervids or their products.
No scientific data that CWD is present in countries outside North America (except
single import to Korea). However further European surveillance necessary.
1.1.8. SSC Opinion on BSE Risk of Autonomic Nervous System, 6-7 March 2003
Infectivity found in vagus nerve and sympathetic mesenteric ganglia of experimental
animals (mice/hamsters) and sheep infected with scrapie. Experimental data from
cattle insufficient, but infectivity in these tissues has not been shown in cattle5 other
than the inconsistent presence of disease-related PrP in the myenteric plexus
(network of nerve fibres throughout muscle of digestive tract) of cattle during the
Unclear whether scrapie models are applicable to pathogenesis of BSE. Cannot
exclude possibility that other autonomic NS structures carry infectivity in BSEinfected
Recommend collection of tissue samples appropriate to improving understanding role
of PNS and particularly the autonomic NS, from field cases and cattle in
4 See also 1.1.2. Experimental Transmission of Chronic Wasting Disease Agent from
Mule Deer to Cattle by Intracerebral Route, Hamir et al.2005, J Vet Diagn Invest
5 The Japanese Institute for Animal Health has detected Western Blot positives in
peripheral nerves in a fallen bovine. Further results are expected in late 2005/early
TSE Roadmap - Scientific Opinions Final Version 6 September 2005
Page 8 of 18
9 EC FAIR CT97 3308 Project
10 Refers to April 2004 SSC Opinion on oral exposure of humans to BSE agent:
infective dose and species barrier. This refers to small amount of tissue that can
contain an infective dose of BSE agent for cattle and sheep ( < 1 gram of
homogenised brain tissue). 2005 data suggests 1mg is sufficient to infect calves.
SNIP...
TSE Roadmap - Scientific Opinions Final Version 6 September 2005
Page 9 of 18
2.3.2. Unpublished Data from VLA, 2005
Unpublished data from a pressure rendering study indicates that BSE infectivity can
survive in tallow recovered by centrifugation and tallow recovered by solvent
extraction.
http://www.seac.gov.uk/papers/tseroadmap05-app3.pdf
Appendix 4 - A Summary of Opinions from the Spongiform
Encephalopathy Advisory Committee (SEAC)
http://www.seac.gov.uk/papers/tseroadmap05-app4.pdf
Importation of Whole Cuts of Boneless Beef from Japan [Docket No. 05-004-1] RIN 0579-AB93 TSS SUBMISSION
http://docket.epa.gov/edkfed/do/EDKStaffItemDetailView?objectId=090007d480993808
http://docket.epa.gov/edkfed/do/EDKStaffAttachDownloadPDF?objectId=090007d480993808
http://docket.epa.gov/edkfed/do/EDKStaffCollectionDetailView?objectId=0b0007d48096b40d
TSS
