• If you are having problems logging in please use the Contact Us in the lower right hand corner of the forum page for assistance.

Prion Disinfectant?????

  • Thread starter Thread starter Anonymous
  • Start date Start date
A

Anonymous

Guest
Iowa company to make disinfectant against Mad Cow disease

by Stella Shaffer

An Iowa bio-products maker has been approved to make a disinfectant used in the fight against Mad Cow disease. Ted Carlson's a quality control manager at the Cedar Rapids plant operated by Genencor which has made bio-products in Cedar Rapids for about a dozen years now. They mainly make industrial enzymes, used in making the ethanol put into your gas, manufacturing the beer or detergent you use, even in the making of artificial snow.

Carlson says he'd guarantee everyone's used one of their products without even knowing it. In the case of Mad Cow, tiny biological agents called prions are blamed for spreading the brain-wasting disease. Meat products contaminated with Mad Cow have been linked to more than 150 human deaths worldwide, mostly in Britain, from a brain-wasting syndrome known as Creutzfeldt-Jakob Disease.

The Cedar Rapids plant has been approved to manufacture "Prionzyme", a new product used to disinfect medical instruments and prevent prions from spreading the disease.

The manufacturing site in Cedar Rapids will have to do more documentation and record-keeping. He says the certification's done so the product can be expected to do what it's supposed to do, and be not only safe for people using it in providing medical care, but also safe for the patient.

The product will be made at first for customers in the medical field. They're targeting medical companies that'll use it to disinfect instruments used in "invasive surgery"...working on your central nervous system, eyes or tonsils, typical areas where the prions have been shown to accumulate within the body.

Later, the line will be developed to offer products that'll sterilize other instruments -- and equipment in meat processing plants. Carlson says it's exciting to take materials made here in Iowa and Midwest, use their fermentation processes, and create products that can be used for everything from filling your car with gas to brewing beer to cleaning medical instruments with what he says it the "most effective of any technique out there."

At first the United Kingdom will be the target market, and production of the Prionzyme will begin once British customers for the product are lined up. If demand is strong, Carlson says the Cedar Rapids Genencor plant could expand its workforce, though that's now happening yet.
 
Shaffer:

The Cedar Rapids plant has been approved to manufacture "Prionzyme", a new product used to disinfect medical instruments and prevent prions from spreading the disease.

The Prion is the disease - they do not spread it since they are actually IT!!. Some reporters sure do make things sound different huh?

I have to wonder if we shall all catch some form of detergent-based illness from the use of this "new" product??? Or will the meat just taste soapy?? :D :D :D :D :wink: :wink:
 
Disinfect?? Inactivate?? Don't they mean de-activate!

Vet Rec. 2006 Mar 18;158(11):361. Related Articles, Links

Inactivation of transmissible spongiform encephalopathy agents during the manufacture of dicalcium phosphate from bone.

Grobben AH, Steele PJ, Somerville RA, Taylor DM.

Delft Gelatin bv, p/a Watergraaflaan 22, 4731 wh Oudenbosch, The Netherlands.

Dicalcium phosphate was prepared from industrial crushed bone artificially contaminated with transmissible spongiform encephalopathy agents in two experiments carried out in an accurately scaled-down laboratory model of the industrial manufacturing process. In one experiment, 10 g of mouse brain infected with the 301v strain of mouse-passaged bovine spongiform encephalopathy agent was added to the crushed bone; in the other experiment, 10 g of hamster brain infected with the 263k strain of hamster-passaged scrapie agent was added. Samples of the infectious brain and dried dicalcium phosphate were assayed for the amount of 301v or 263k infectivity present. The titre of infectivity of the 301v-infected brain was 10(7.7) intracerebral id50/g; that of the 263k-infected brain was 10(8.0) intracerebral id50/g. The titres of the dried samples of dicalcium phosphate were 10(2.5) id50/g in the experiment spiked with 301v and 10(2.7) id50/g in the experiment spiked with 263k. The calculated clearance factors were 10(3.9) for the experiment with 301v and 10(3.8) for the experiment with 263k.
PMID: 16547182

This is twice now, that cow bones have been used to sequester heavy metals including/but not limited to: uranium and strontium.

I don't know what enzymes the Cedar Rapids fellow might use, since PrPSc prions are protease resistant. Perhaps they will use a manganese based anti-oxidant type compound?

MnSOD (manganese superoxide dismutase) is one of the cell's leading defenders against oxidative damage to the mitochondria.

Prusiner uses polyoxometalate complexes to bind prions in brain homogenate samples, perhaps Cedar Rapids will employ one of these metallocomplex anions. eg: Keggin POM - [H2W12O40]6-

Dr. Stanley Prusiner stated "Our results suggest that prion aggregation may involve multivalent electrostatic interactions between the POM anions and positively charged cleft sites of PrPSc." POM - standing for polyoxometallate complex. The negative charge (or anion) of the POM will bind to the postive charge (or cation) of the prion.

Prusiner also states, "...a higher binding affinity can be expected for the more highly charged anions..." Since copper can only have +1 or +2 valence (shells), it is extremely unlikely that these POM complexes would bind the health PrPC which is bond to copper. The unhealthy PrPSc must have an ion(s) with a higher valence capacity, some examples of this are:

Americium 3,4,5,6 valences
Astatine 1,3,5,7
Chlorine 1,3,5,7
Iodine 1,5,7
Iridium 2,3,4,6
Manganese 2,3,4,6,7*
Molybdenum 2,3,4,5,6
Neptunium 3,4,5,6
Nitrogen 1,2,3,4,5
Osmium 2,3,4,6,8
Phosphorous 3,4,5
Plutonium 3,4,5,6
Protactinium 4,5
Rhenium 1,2,4,6,7
Ruthenium 2,3,4,6,8
Selenium 2,4,6
Sulphur 2,4,6
Tantalum 5
Technetium 4,6,7
Tellurium 2,4,6
Tungsten 2,3,4,5,6
Uranium 3,4,5,6
Vanadium 2,3,4,5

What this means is the nucleating centers of PrPSc prions are rogue metals.[/i]
 

Latest posts

Back
Top